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3.D.4.4.1
Cytochrome oxidase including heme A synthase (HAS) and 4 subunits of the cytochrome oxidase.  The 3-d structure of heme A synthase (of 306 aas and 8 TMSs) at 2.2 Å resolution has been solved revealing that the N- and C-terminal halves of HAS consist of four-helix bundles and they align in a pseudo twofold symmetry manner. Each bundle contains a pair of histidine residues and forms a heme-binding domain. The C-half domain binds a cofactor-heme molecule, while the N-half domain is vacant (Niwa et al. 2018). The Sco1 protein, YpmQ, is an accessory protein involved in the assembly of cytochrome c oxidase (Andrews et al. 2004).

Accession Number:P24011
Protein Name:Cytochrome c oxidase subunit 2
Length:356
Molecular Weight:40095.00
Species:Bacillus subtilis [1423]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

Entrez Gene ID: 936789   
Pfam: PF00116    PF02790    PF00034   
KEGG: bsu:BSU14890   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0070469 C:respiratory chain
GO:0005507 F:copper ion binding
GO:0004129 F:cytochrome-c oxidase activity
GO:0009055 F:electron carrier activity
GO:0020037 F:heme binding
GO:0022904 P:respiratory electron transport chain

References (2)

[1] “The Bacillus subtilis cytochrome-c oxidase. Variations on a conserved protein theme.”  Saraste M.et.al.   1847686
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MVKHWRLILL LALVPLLLSG CGKPFLSTLK PAGEVADKQY DLTVLSTLIM VVVVAVVSVI 
61:	FFYVIVRFRR SRVGENTIPK QVEGNKFLEI TWTVIPILLL IILVIPVVLY TLELADTSPM 
121:	DKKGRKAEDA LVVNVRANLY WWEFEYPDYG IITSQELIVP TDQRVYFNLK ASDVKHSFWI 
181:	PSVGGKLDTN TDNENKFFLT FDSKRSKEAG DMFFGKCAEL CGPSHALMDF KVKTMSAKEF 
241:	QGWTKEMKNY KSTAESDLAK QGEELFKEKN CLSCHAVEPN DKRAEAARTA PNLATFGERT 
301:	KVAGVKEANK ENVKAWLKDP DSIKPGNKMT GTYPKLSDSE TNALYEYLKG LKAESK