8.A.152.1.9
The receptor for interleukin-4 (IL4) and interleukin-13 (IL13), of 825 aas and 2 TMSs, one N-terminal and one about 30% from the N-terminus, and 427 aas and 2 TMSs, one N-terminal and one C-terminal, respectively. Signaling through the interleukin-4/interleukin-13 receptor complexes regulates cholangiocyte TMEM16A (TC# 1.A.17.1.1) expression and biliary secretion (Dutta et al. 2020). The IL4/IL13 responses are involved in regulating
IgE production, and chemokine and mucus production at sites of allergic
inflammation. In certain cell types, it can signal through activation of
insulin receptor substrates, IRS1/IRS2 (Keegan et al. 1994).
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| Accession Number: | P24394 |
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| Protein Name: | Interleukin-4 receptor subunit alpha |
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| Length: | 825 |
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| Molecular Weight: | 89658.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG PTNCSTELRL
61: LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT LDLWAGQQLL WKGSFKPSEH
121: VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD NYLYNHLTYA VNIWSENDPA DFRIYNVTYL
181: EPSLRIAAST LKSGISYRAR VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS
241: CIVILAVCLL CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP
301: HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV LWPESISVVR
361: CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE GIVARLTESL FLDLLGEENG
421: GFCQQDMGES CLLPPSGSTS AHMPWDEFPS AGPKEAPPWG KEQPLHLEPS PPASPTQSPD
481: NLTCTETPLV IAGNPAYRSF SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT
541: TVPQPEPETW EQILRRNVLQ HGAAAAPVSA PTSGYQEFVH AVEQGGTQAS AVVGLGPPGE
601: AGYKAFSSLL ASSAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV PLFTFGLDRE
661: PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT DPLVDSLGSG IVYSALTCHL
721: CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD RSSPPTTPLR APDPSPGGVP LEASLCPASL
781: APSGISEKSK SSSSFHPAPG NAQSSSQTPK IVNFVSVGPT YMRVS