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3.A.1.203.6
Peroxisomal long-chain fatty acid/oleic acid importer, PXA1 (Pat2)/PXA2 (Pat1) (Lamping et al., 2010; van Roermund et al., 2011).  PXA1 and PXA2 are two half-ABC transport subunits that can form a heterodimer. They are of 870 and 853 aas, respectively, both probably with 6 TMSs in a 1 + 2 + 2 + 1 TMS arrangement. Oxidation of its substrates requires the peroxysomal fatty acyl CoA ligase, suggesting that the free acids are the transported substrates.   

Accession Number:P34230
Protein Name:PXA2 aka Pat1 aka YKL188C aka aka YKL741
Length:853
Molecular Weight:97126.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Peroxisome membrane1 / Multi-pass membrane protein2
Substrate long-chain fatty acid, oleic acid

Cross database links:

DIP: DIP-741N DIP-741N
RefSeq: NP_012733.1   
Entrez Gene ID: 853647   
Pfam: PF06472    PF00005   
KEGG: sce:YKL188C   

Gene Ontology

GO:0005779 C:integral to peroxisomal membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0005515 F:protein binding
GO:0015908 P:fatty acid transport
GO:0055085 P:transmembrane transport
GO:0042626 F:ATPase activity, coupled to transmembrane movement of substances

References (10)

[1] “A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters.”  Shani N.et.al.   8876235
[2] “Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene.”  Wiemann S.et.al.   8154185
[3] “The yeast YKL741 gene situated on the left arm of chromosome XI codes for a homologue of the human ALD protein.”  Bossier P.et.al.   7941751
[4] “Complete DNA sequence of yeast chromosome XI.”  Dujon B.et.al.   8196765
[5] “The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae.”  Hettema E.H.et.al.   8670886
[6] “A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters.”  Shani N.et.al.   8876235
[7] “Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene.”  Wiemann S.et.al.   8154185
[8] “The yeast YKL741 gene situated on the left arm of chromosome XI codes for a homologue of the human ALD protein.”  Bossier P.et.al.   7941751
[9] “Complete DNA sequence of yeast chromosome XI.”  Dujon B.et.al.   8196765
[10] “The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae.”  Hettema E.H.et.al.   8670886

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MISTASAFYQ KHRVNLLRSS YIILLLATLY NSNSSSSNNK TDKKDSESTV LENKKIEEGK 
61:	ETAVDREEDE SSKEELTIVS KHSTDSEDGA IIIDKESKTN HKGGERKGKV DFLFKLLLHD 
121:	KKCLILFITQ AILLNIRTLL SLRVATLDGQ LVSTLVRAQY ANFTKILLGK WMILGIPASF 
181:	INSLISYTTK LCAVTINRKV SDFLLSKYLS NHHTFYSVAS AESVSEIQDN LTKDIYTFSM 
241:	NSSLLLNQLL KPMLDLILCS FKLLTSNTSV MGEGTLALGL IVYASNSLLK LIQPNFTRLT 
301:	MASASLESWF RSLHSNLHSS NEEIALLRGQ KRELENVDYS FYRLVLFLNR EIKARAIYDV 
361:	ATAFVIKYTW GAAGLVLCSI PIFFKNKPSE DTLQLKEPGN DMTADFITNR RLLVTASSSI 
421:	GRFVELKRNI QQLRGIRLRL NKFNDLLDAN KGDDEKEPRD ERCIVEYDDS RIKFENIPLI 
481:	TPANQVLVPE LSFDLKHGNH LLIIGPNGCG KSSLFRILGG LWPIRATPNK NHQSKLIMPR 
541:	RTVDRDCAIF YLPQRPYMGN RSTFREQIIY PDSIEQFKER YHNDYDLGDA DLIKILQLLD 
601:	LEDLVTENMS LLLAQRTSKN DSQQLSTEDN QSPCAIKVRD AFSIVRNWSE ELTIGVQQRL 
661:	AMARMYYHKP KFAVLDECTS AVAPEMEQRM YENAQNFGIS LISVCHRTSL WHFHNYLLKF 
721:	DGKGGYQFGP FNPKERLCNE EKLLELNAIL DQQVPLWERK LKDLTIAKES NIIRKSETNL 
781:	NLFEKIEDPK TSKSNALFNA NKGQRITSPT GQETSKRLPL FSQPSSSASS NLLRNNKSLN 
841:	KKVKTKKEEG KER