3.A.29.1.2
Mitochondrial AAA protease complex of two enzymes, Yta10/12 (Afg3-like or Spg-7) and Yta11 (Ymel-1). It is a mitochondrial
ATP-dependent metalloprotease complex mediating degradation of non-assembled
mitochondrial inner membrane proteins and
necessary for the assembly of the mitochondrial respiratory chain and ATPase
complexes. It functions both in post-translational
assembly and in the turnover of mistranslated or misfolded polypeptides
(Nargund et al. 2012, Pellegrino et al. 2014, Nargund et al. 2015).
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| Accession Number: | P54813 |
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| Protein Name: | ATP-dependent zinc metalloprotease YME1 homolog |
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| Length: | 723 |
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| Molecular Weight: | 79831.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion inner membrane1 |
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| Substrate |
protein |
|---|
1: MQSAINLNIG GLLQNTGLLR NSRNGINRKP LDIEATAASL SRVYHQVWRQ FSSDTSSPVT
61: INQMNNILRD STLSRRIARK SEISLNYDDA VVRIIPASSS FYIQRRGFRT RKQTFGVGNA
121: GKPTQDEVKS PLTYFSELLA GKKQKTSEGG VEKWNQYESD LKKLPENQQR TYTDGFVKGL
181: LSNGVSGAGK DGKKSNTLTR FYIFLVFCIF FGYLTGRIRV RVGDRQIGSL FFSNPQEVNP
241: EDVQVTFDDV RGMDEAKLEV EEIVDYLKDP EKYSRLGGRL PKGVLLVGPP GTGKTLLARA
301: IAGEAQVPFF HTAGSEFDEV LVGQGARRVR DLFDKAKARA PCIIFIDEID SVGSKRVSNS
361: IHPYANQTIN QLLSEMDGFT RNEGIIVIAA TNRVDDLDKA LLRPGRFDVR VTVPKPDLAG
421: RVDIFNFYLS KIVHSGGIDP KVLAKGSTGF TGADIENMVN QAALKAATDN AVEVTMAYLD
481: EARDRVLMGP ARTGGRIPDE EANRNTAYHE AGHTLVSLYT KDATPLHKVT IIPRGQSLGH
541: TAMLPEKDSY QLTKAQMLAT LDVMMGGRVA EELIFGDDKV TTGAADDLSK ATQLAVQMVK
601: VFGMSDKVGL RDFTAQDNES ALVKVSDLAP QTAELIDAEI NRVLQESYKR AKVILETKKK
661: EHQLLAEALL EYETLSADEV KRVISGQKIK RPTPAAVKKS NETKRNQPSL VLHLFEEEGR
721: GKQ