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1.B.46.1.1
The lipoprotein insertase, LolAB, of Gram-negative bacteria.  Genetic analysis revealed a robust and hierarchical recruitment of the LolA chaperone protein to the LolCDE lipoprotein transporter (Lehman et al. 2024).

Accession Number:P61320
Protein Name:LolB
Length:207
Molecular Weight:23551.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Lipid-anchor2
Substrate lipoprotein

Cross database links:

DIP: DIP-35933N
RefSeq: AP_001834.1    NP_415727.1   
Entrez Gene ID: 945775   
Pfam: PF03550   
BioCyc: EcoCyc:EG11293-MONOMER    ECOL168927:B1209-MONOMER   
KEGG: ecj:JW1200    eco:b1209   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0030228 F:lipoprotein receptor activity
GO:0008565 F:protein transporter activity
GO:0015031 P:protein transport

References (9)

[1] “Cloning and characterization of genes involved in the biosynthesis of delta-aminolevulinic acid in Escherichia coli.”  Ikemi M.et.al.   1427085
[2] “Characterization of the hemA-prs region of the Escherichia coli and Salmonella typhimurium chromosomes: identification of two open reading frames and implications for prs expression.”  Post D.A.et.al.   7679718
[3] “Expression of genes kdsA and kdsB involved in 3-deoxy-D-manno-octulosonic acid metabolism and biosynthesis of enterobacterial lipopolysaccharide is growth phase regulated primarily at the transcriptional level in Escherichia coli K-12.”  Strohmaier H.et.al.   7543480
[4] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[5] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[6] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[7] “A novel outer membrane lipoprotein, LolB (HemM), involved in the LolA (p20)-dependent localization of lipoproteins to the outer membrane of Escherichia coli.”  Matsuyama S.et.al.   9384574
[8] “Deletion of lolB, encoding an outer membrane lipoprotein, is lethal for Escherichia coli and causes accumulation of lipoprotein localization intermediates in the periplasm.”  Tanaka K.et.al.   11673422
[9] “Crystal structures of bacterial lipoprotein localization factors, LolA and LolB.”  Takeda K.et.al.   12839983
Structure:
1IWM   1IWN     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MPLPDFRLIR LLPLAALVLT ACSVTTPKGP GKSPDSPQWR QHQQDVRNLN QYQTRGAFAY 
61:	ISDQQKVYAR FFWQQTGQDR YRLLLTNPLG STELELNAQP GNVQLVDNKG QRYTADDAEE 
121:	MIGKLTGMPI PLNSLRQWIL GLPGDATDYK LDDQYRLSEI TYSQNGKNWK VVYGGYDTKT 
181:	QPAMPANMEL TDGGQRIKLK MDNWIVK