TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.5.1
Oligopeptide porter (also takes up amino glycoside antibiotics such as kanamycin, streptomycin and neomycin as well as cell wall-derived peptides such as murein tripeptide). It transports substrate peptides of 2-5 amino acids with highest affinity for tripeptides. Also transports δ-aminolevulinic acid (ALA). [May be regulated by PTS Enzyme INtr-aspartokinase.] ATP-binding to OppDF may result in donation of peptide to OppBC and simultaneous release of OppA (Doeven et al., 2008).

Accession Number:P77348
Protein Name:MppA aka B1329
Length:537
Molecular Weight:59900.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Periplasm1
Substrate oligopeptide

Cross database links:

RefSeq: AP_001957.1    NP_415845.2   
Entrez Gene ID: 945951   
Pfam: PF00496   
BioCyc: EcoCyc:G6665-MONOMER    ECOL168927:B1329-MONOMER   
KEGG: ecj:JW1322    eco:b1329   

Gene Ontology

GO:0042597 C:periplasmic space
GO:0005215 F:transporter activity
GO:0015031 P:protein transport
GO:0042939 P:tripeptide transport

References (4)

[1] “MppA, a periplasmic binding protein essential for import of the bacterial cell wall peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate.”  Park J.T.et.al.   9495761
[2] “A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.”  Aiba H.et.al.   9097039
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
Structure:
3O9P   4TOZ     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MKHSVSVTCC ALLVSSISLS YAAEVPSGTV LAEKQELVRH IKDEPASLDP AKAVGLPEIQ 
61:	VIRDLFEGLV NQNEKGEIVP GVATQWKSND NRIWTFTLRD NAKWADGTPV TAQDFVYSWQ 
121:	RLVDPKTLSP FAWFAALAGI NNAQAIIDGK ATPDQLGVTA VDAHTLKIQL DKPLPWFVNL 
181:	TANFAFFPVQ KANVESGKEW TKPGNLIGNG AYVLKERVVN EKLVVVPNTH YWDNAKTVLQ 
241:	KVTFLPINQE SAATKRYLAG DIDITESFPK NMYQKLLKDI PGQVYTPPQL GTYYYAFNTQ 
301:	KGPTADQRVR LALSMTIDRR LMTEKVLGTG EKPAWHFTPD VTAGFTPEPS PFEQMSQEEL 
361:	NAQAKTLLSA AGYGPQKPLK LTLLYNTSEN HQKIAIAVAS MWKKNLGVDV KLQNQEWKTY 
421:	IDSRNTGNFD VIRASWVGDY NEPSTFLTLL TSTHSGNISR FNNPAYDKVL AQASTENTVK 
481:	ARNADYNAAE KILMEQAPIA PIYQYTNGRL IKPWLKGYPI NNPEDVAYSR TMYIVKH