8.A.152.1.9
The receptor for interleukin-4 (IL4) and interleukin-13 (IL13), of 825 aas and 2 TMSs, one N-terminal and one about 30% from the N-terminus, and 427 aas and 2 TMSs, one N-terminal and one C-terminal, respectively. Signaling through the interleukin-4/interleukin-13 receptor complexes regulates cholangiocyte TMEM16A (TC# 1.A.17.1.1) expression and biliary secretion (Dutta et al. 2020). The IL4/IL13 responses are involved in regulating
IgE production, and chemokine and mucus production at sites of allergic
inflammation. In certain cell types, it can signal through activation of
insulin receptor substrates, IRS1/IRS2 (Keegan et al. 1994).
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| Accession Number: | P78552 |
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| Protein Name: | Interleukin-13 receptor subunit alpha-1 |
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| Length: | 427 |
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| Molecular Weight: | 48760.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MEWPARLCGL WALLLCAGGG GGGGGAAPTE TQPPVTNLSV SVENLCTVIW TWNPPEGASS
61: NCSLWYFSHF GDKQDKKIAP ETRRSIEVPL NERICLQVGS QCSTNESEKP SILVEKCISP
121: PEGDPESAVT ELQCIWHNLS YMKCSWLPGR NTSPDTNYTL YYWHRSLEKI HQCENIFREG
181: QYFGCSFDLT KVKDSSFEQH SVQIMVKDNA GKIKPSFNIV PLTSRVKPDP PHIKNLSFHN
241: DDLYVQWENP QNFISRCLFY EVEVNNSQTE THNVFYVQEA KCENPEFERN VENTSCFMVP
301: GVLPDTLNTV RIRVKTNKLC YEDDKLWSNW SQEMSIGKKR NSTLYITMLL IVPVIVAGAI
361: IVLLLYLKRL KIIIFPPIPD PGKIFKEMFG DQNDDTLHWK KYDIYEKQTK EETDSVVLIE
421: NLKKASQ