TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.D.4.4.3
The proton pumping Caa3-type cytochrome oxidase chains A-F. The crystal structure (PDB: 2YEV) is known (2.36Å resolution; Lyons et al., 2012). It has a covalently teathered cytochrome c domain. In the cytochrome aa3, O2 molecules that arrive at the reduction site diffuse through the X-ray-observed tunnel, supporting its role as the main O2 delivery pathway in this cytochrome ba3 as well as the cytochrome aa3 of Rhodobacter spheroides (Mahinthichaichan et al. 2018).

Accession Number:P98005
Protein Name:Cytochrome c oxidase polypeptide I+III
Length:791
Molecular Weight:89214.00
Species:Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [300852]
Number of TMSs:19
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

Entrez Gene ID: 3168081   
Pfam: PF00115    PF00510   
KEGG: ttj:TTHA0312   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0070469 C:respiratory chain
GO:0005507 F:copper ion binding
GO:0004129 F:cytochrome-c oxidase activity
GO:0009055 F:electron carrier activity
GO:0020037 F:heme binding
GO:0009060 P:aerobic respiration
GO:0006119 P:oxidative phosphorylation
GO:0022904 P:respiratory electron transport chain

References (2)

[1] “Cytochrome oxidase genes from Thermus thermophilus. Nucleotide sequence of the fused gene and analysis of the deduced primary structures for subunits I and III of cytochrome caa3.”  Mather M.W.et.al.   8383670
[2] “Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase.”  Buse G.et.al.   10338009
Structure:
2YEV     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MAITAKPKAG VWAVLWDLLT TVDHKKIGLM YTATAFFAFA LAGVFSLLIR TQLAVPNNQF 
61:	LTGEQYNQIL TLHGATMLFF FIIQAGLTGF GNFVVPLMLG ARDVALPRVN AFSYWAFLGA 
121:	IVLALMSYFF PGGAPSVGWT FYYPFSAQSE SGVDFYLAAI LLLGFSSLLG NANFVATIYN 
181:	LRAQGMSLWK MPIYVWSVFA ASVLNLFSLA GLTAATLLVL LERKIGLSWF NPAVGGDPVL 
241:	FQQFFWFYSH PTVYVMLLPY LGILAEVAST FARKPLFGYR QMVWAQMGIV VLGTMVWAHH 
301:	MFTVGESTLF QIAFAFFTAL IAVPTGVKLF NIIGTLWGGK LQMKTPLYWV LGFIFNFLLG 
361:	GITGVMLSMT PLDYQFHDSY FVVAHFHNVL MAGSGFGAFA GLYYWWPKMT GRMYDERLGR 
421:	LHFWLFLVGY LLTFLPQYAL GYLGMPRRYY TYNADIAGWP ELNLLSTIGA YILGLGGLVW 
481:	IYTMWKSLRS GPKAPDNPWG GYTLEWLTAS PPKAHNFDVK LPTEFPSERP LYDWKKKGVE 
541:	LKPEDPAHIH LPNSSFWPFY SAATLFAFFV AVAALPVPNV WMWVFLALFA YGLVRWALED 
601:	EYSHPVEHHT VTGKSNAWMG MAWFIVSEVG LFAILIAGYL YLRLSGAATP PEERPALWLA 
661:	LLNTFLLVSS SFTVHFAHHD LRRGRFNPFR FGLLVTIILG VLFFLVQSWE FYQFYHHSSW 
721:	QENLWTAAFF TIVGLHGLHV VIGGFGLILA YLQALRGKIT LHNHGTLEAA SMYWHLVDAV 
781:	WLVIVTIFYV W