3.A.7.18.2 Type IV-like, Tad-like protein secretion system, the Kil system, potentially containing up to 21 proteins. The genes of this system are encoded within two gene clusters, MXAN_3102-3108 and MXAN_4648-4661. All 21 gene products are included within this TC entry although it is not established that all participate in secretion. The descriptions of the proteins are as listed in UNIPROT. Myxococcus xanthus, a soil bacterium, predates collectively using
motility to invade prey colonies. Prey lysis is mostly thought to rely
on secreted factors, cocktails of antibiotics and enzymes as well as direct
contact with Myxococcus cells. Seef et al. 2021 showed that on
surfaces, the coupling of A-motility and contact-dependent killing is the
central predatory mechanism driving effective prey colony invasion and
consumption. At the molecular level, contact-dependent killing involves a type IV filament-like machinery (Kil) that both
promotes motility arrest and prey cell plasmolysis. In this process, Kil
proteins assemble at the predator-prey contact site, suggesting that
they allow tight contact with prey cells for their intoxication.
Kil-like systems form a new class of Tad-like machineries in predatory
bacteria, suggesting a conserved function in predator-prey interactions.
The system allows a novel cell-cell interaction function for
bacterial pilus-like assemblages (Seef et al. 2021).
|
Accession Number: | Q1D3F0 |
Protein Name: | Uncharacterized protein |
Length: | 283 |
Molecular Weight: | 31223.00 |
Species: | Myxococcus xanthus (strain DK1622) [246197] |
Number of TMSs: | 2 |
Substrate |
protein |
---|
1: MTRPTRMPAR RPRRMTSKTS RFPVSRVVAA RTALLCVLLA SVPAAAEQEL PIYPGTIHTR
61: IGNDLVIGGE YYRLAYFTTP DPMEKVAAYF ARKWQEEGYP TVVEGDMQDE GVVSALYTRE
121: GLQRGVVLRK HLGKTVGFTA LRDLWVRPPK KPAPGLVALE GALYSQDLAT RDDPGGSQSR
181: TTLVTGELTK VQQQVNAELE RRGYAPVRQS ALKMGGGTQL TMEHARKGEQ VVTTLSPTDE
241: GVTAVVQMWI GSDRPDAVPN DDAVRQSREA YERDQAQKKE GAK