3.A.1.14.10
The heme porter, Shp/SiaABC (HtsABC). Shp is a cell surface heme binding protein that transfers the heme directly to HstA (Nygaard et al., 2006). The crystal structure of the heme binding domain of Shp has been solved (Aranda et al., 2007). HtsABC is required for the uptake of staphyloferrin A (Beasley et al. 2009). The Shp cell surface heme receptor feeds iron-heme to the transporter in preparation for uptake (Sun et al. 2010; Ouattara et al., 2010).
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| Accession Number: | Q1J548 |
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| Protein Name: | Putative uncharacterized protein shp |
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| Length: | 291 |
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| Molecular Weight: | 32404.00 |
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| Species: | Streptococcus pyogenes serotype M4 (strain MGAS10750) [370554] |
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| Number of TMSs: | 2 |
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| Substrate |
ferroheme b |
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| Entrez Gene ID: |
4067389
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| Pfam: |
PF11545
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| KEGG: |
spi:MGAS10750_S
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[1] “Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus.” Beres S.B. et.al. 16636287
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1: MTKVVIKQLL QVIVVFMISL STMTGVVYAD KGQIYGCIIQ RNYRHPISGQ IEDSGGEHSF
61: DIGQGMVEGT VYSDAMLEVS DAGKIVLTFR MSLADYSGNY QFWIQPGGTG SFQAVDYNIT
121: QKGTDTNGTA LDIAISLPTV NSIIRGSMFV EPMGREVVFY LSASELIQKY SGNMLAQLVT
181: ETDNSQNQEV KDNQKPVDTK LGESQDESHT GAMITQNKPK ANSSNNKSLS DKKILPSKMG
241: LTTSLELKKE DKFRSKKDLS IMIYYFPTFF LMLGGFAVWV WKKRKKNDKT M