2.A.6.2.29
The AdeIJK MDR pump (contributes to resistance to β-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim, acridine, safranin, pyronine, triclosan and sodium dodecyl sulfate) (Damier-Piolle et al., 2008; Fernando et al. 2014Fernando et al. 2014)
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| Accession Number: | Q24LT7 |
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| Protein Name: | AdeJ |
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| Length: | 1058 |
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| Molecular Weight: | 114569.00 |
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| Species: | Acinetobacter baumannii [470] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
fluoroquinolone antibiotic, rifampicin, trimethoprim, chloramphenicol, beta-lactam, novobiocin, fusidic acid, tetracycline, tigecycline, triclosan, erythromycin A, safranin O, pyronin Y, sodium dodecyl sulfate, acridine |
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| Pfam: |
PF00873
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[1] “AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in Acinetobacter baumannii.” Damier-Piolle L. et.al. 18086852
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1: MAQFFIHRPI FAWVIALVIM LAGILTLTKM PIAQYPTIAP PTVTIAATYP GASAETVENT
61: VTQIIEQQMN GLDGLRYISS NSAGNGQASI QLNFEQGVDP DIAQVQVQNK LQSATALLPE
121: DVQRQGVTVT KSGASFLQVI AFYSPDNNLS DSDIKDYVNS SIKEPLSRVA GVGEVQVFGG
181: SYAMRIWLDP AKLTSYQLTP SDIATALQAQ NSQVAVGQLG GAPAVQGQVL NATVNAQSLL
241: QTPEQFKNIF LKNTASGAEV RLKDVARVEL GSDNYQFDSK FNGKPAAGLA IKIATGANAL
301: DTAEAVEQRL SELRKNYPTG LADKLAYDTT PFIRLSIESV VHTLIEAVIL VFIVMFLFLQ
361: NWRATIIPTL AVPVVVLGTF AVINIFGFSI NTLTMFAMVL AIGLLVDDAI VVVENVERVM
421: SEDHTDPVTA TSRSMQQISG ALVGITSVLT AVFVPMAFFG GTTGVIYRQF SITLVTAMVL
481: SLIVALTFTP ALCATILKQH DPNKEPSNNI FARFFRSFNN GFDRMSHSYQ NGVSRMLKGK
541: IFSGVLYAVV VALLVFLFQK LPSSFLPEED QGVVMTLVQL PPNATLDRTG KVIDTMTNFF
601: MNEKDTVESI FTVSGFSFTG VGQNAGIGFV KLKDWSKRTT PETQIGSLIQ RGMALNMIIK
661: DASYVMPLQL PAMPELGVTA GFNLQLKDSS GQGHEKLIAA RNTILGLASQ DKRLVGVRPN
721: GQEDTPQYQI NVDQAQAGAM GVSIAEINNT MRIAWGGSYI NDFVDRGRVK KVYVQGDAGS
781: RMMPEDLNKW YVRNNKGEMV PFSAFATGEW TYGSPRLERY NGVSSVNIQG TPAPGVSSGD
841: AMKAMEEIIG KLPSMGLQGF DYEWTGLSLE ERESGAQAPF LYALSLLIVF LCLAALYESW
901: SIPFSVLLVV PLGVIGAIVL TYLGMIIKGD PNLSNNIYFQ VAIIAVIGLS AKNAILIVEF
961: AKELQEKGED LLDATLHAAK MRLRPIIMTT LAFGFGVLPL ALSTGAGAGS QHSVGFGVLG
1021: GVLSATFLGI FFIPVFYVWI RSMFKYKPKT INTQEHKS