2.A.6.2.44
Multidrug efflux pump, AdeFGH. Mediates high level resistance to chloramphenicol, clindamycin, fluoroquinolones, carbapenem and
trimethoprim and decreased susceptibility to tetracycline-tigecycline
and sulfonamides;
susceptibility to β-lactams, erythromycin, aminoglycosides and rifampin was not
affected. It also mediates increased resistance to ethidium bromide,
safranin O, acridine orange, trimethoprim and
sulfamethoxazole (Coyne et al. 2010; AlQumaizi et al. 2022).
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| Accession Number: | Q2FD81 |
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| Protein Name: | Cation/multidrug efflux pump |
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| Length: | 1059 |
|---|
| Molecular Weight: | 114214.00 |
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| Species: | Acinetobacter baumannii [470] |
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| Number of TMSs: | 12 |
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| Substrate |
fluoroquinolone antibiotic, trimethoprim, chloramphenicol, safranin O, ethidium bromide, acridine orange free base, clindamycin, sulfanilamide, sulfamethoxazole |
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1: MNISKFFIDR PIFAGVLSVL ILLAGLLSVF QLPISEYPEV VPPSVVVRAQ YPGANPKVIA
61: ETVASPLEES INGVEDMLYM QSQANSDGNL TITVNFKLGI DPDKAQQLVQ NRVSQAMPRL
121: PEDVQRLGVT TLKSSPTLTM VVHLTSPDNR YDMTYLRNYA VLNVKDRLAR LQGVGEVGLF
181: GSGDYAMRVW LDPQKVAQRN LTATEIVNAI REQNIQVAAG TIGASPSNSP LQLSVNAQGR
241: LTTEQEFADI ILKTAPDGAV TRLGDVARVE LAASQYGLRS LLDNKQAVAI PIFQAPGANA
301: LQVSDQVRST MKELSKDFPS SIKYDIVYDP TQFVRASIKA VVHTLLEAIT LVVVVVILFL
361: QTWRASIIPL LAVPVSIIGT FALMLAFGYS INALSLFGMV LAIGIVVDDA IVVVENVERN
421: IEAGLNPREA TYRAMREVSG PIIAIALTLV AVFVPLAFMT GLTGQFYKQF AMTIAISTVI
481: SAFNSLTLSP ALAALLLKGH DAKPDALTRI MNRVFGRFFA LFNRVFSRAS DRYSQGVSRV
541: ISHKASAMGV YAALLGLTVG ISYIVPGGFV PAQDKQYLIS FAQLPNGASL DRTEAVIRKM
601: SDTALKQPGV ESAVAFPGLS INGFTNSSSA GIVFVTLKPF DERKAKDLSA NAIAGALNQK
661: YSAIQDAYIA VFPPPPVMGL GTMGGFKLQL EDRGALGYSA LNDAAQNFMK AAQSAPELGP
721: MFSSYQINVP QLNVDLDRVK AKQQGVAVTD VFNTMQIYLG SQYVNDFNRF GRVYQVRAQA
781: DAPFRANPED ILQLKTRNSA GQMVPLSSLV NVTQTYGPEM VVRYNGYTSA DINGGPAPGY
841: SSSQAEAAVE RIAAQTLPRG IKFEWTDLTY QKILAGNAGL WVFPISVLLV FLVLAAQYES
901: LTLPLAVILI VPMGILAALT GVWLTAGDNN IFTQIGLMVL VGLACKNAIL IVEFARELEM
961: QGATAFKAAV EASRLRLRPI LMTSIAFIMG VVPLVTSTGA GSEMRHAMGV AVFFGMIGVT
1021: FFGLFLTPAF YVLIRTLNSK HKLHSAAVHE APLASPHDH