2.A.6.2.44
Multidrug efflux pump, AdeFGH. Mediates high level resistance to chloramphenicol, clindamycin, fluoroquinolones, carbapenem and
trimethoprim and decreased susceptibility to tetracycline-tigecycline
and sulfonamides;
susceptibility to β-lactams, erythromycin, aminoglycosides and rifampin was not
affected. It also mediates increased resistance to ethidium bromide,
safranin O, acridine orange, trimethoprim and
sulfamethoxazole (Coyne et al. 2010; AlQumaizi et al. 2022).
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| Accession Number: | Q2FD82 |
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| Protein Name: | Putative RND family drug transporter |
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| Length: | 406 |
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| Molecular Weight: | 43442.00 |
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| Species: | Acinetobacter baumannii [470] |
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| Number of TMSs: | 1 |
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| Substrate |
fluoroquinolone antibiotic, trimethoprim, chloramphenicol, safranin O, ethidium bromide, acridine orange free base, clindamycin, sulfanilamide, sulfamethoxazole |
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1: MSFSRKQFAL SAIFVAILAT GGSFMLLHEN ADAKAAPTAA QQAATVDVAP VVSKTITDWQ
61: EYSGRLEAID QVDIRPQVSG KLIAVHFKDG SLVKKGDLLF TIDPRPFEAE LNRAKAQLAS
121: AEAQVTYTAS NLSRIQRLIQ SNAVSRQELD LAENDARSAN ANLQAARAAV QSARLNLEYT
181: RITAPVSGRI SRAEVTVGNV VSAGNGAQVL TSLVSVSRLY ASFDVDEQTY LKYISNQRNS
241: AQVPVYMGLA NETGFTREGT INSIDNNLNT TSGTIRVRAT FDNPNGVLLP GLYARIRLGG
301: GQPRPAILIS PTAVGVDQDK RFVVVVDAKN QTAYREVKLG AQQDGLQIVN SGLQAGDRIV
361: VNGLQRIRPG DPVTPHLVPM PNSQITASAT PPQPQPTDKT STPAKG