2.A.6.2.29
The AdeIJK MDR pump (contributes to resistance to β-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim, acridine, safranin, pyronine, triclosan and sodium dodecyl sulfate) (Damier-Piolle et al., 2008; Fernando et al. 2014Fernando et al. 2014)
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| Accession Number: | Q2FD95 |
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| Protein Name: | AdeI |
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| Length: | 416 |
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| Molecular Weight: | 43806.00 |
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| Species: | Acinetobacter baumannii [470] |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
fluoroquinolone antibiotic, rifampicin, trimethoprim, chloramphenicol, beta-lactam, novobiocin, fusidic acid, tetracycline, tigecycline, triclosan, erythromycin A, safranin O, pyronin Y, sodium dodecyl sulfate, acridine |
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| Pfam: |
PF00529
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[1] “AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in Acinetobacter baumannii.” Damier-Piolle L. et.al. 18086852
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1: MMSAKLWAPA LTACALATSI ALVGCSKGSD EKQQAAAAQK MPPAEVGVIV AQPQSVEQSV
61: ELSGRTSAYQ ISEVRPQTSG VILKRLFAEG SYVREGQALY ELDSRTNRAT LENAKASLLQ
121: QQANLASLRT KLNRYKQLVS SNAVSKQEYD DLLGQVNVAE AQVAAAKAQV TNANVDLGYS
181: TIRSPISGQS GRSSVTAGAL VTANQTDPLV TIQQLDPIYV DINQSSAELL RLRQQLSKGS
241: LNNSNNTKVK LKLEDGSTYP IEGQLAFSDA SVNQDTGTIT LRAVFSNPNH LLLPGMYTTA
301: QIVQGVVPNA YLIPQAAITR LPTGQAVAML VNAKGVVESR PVETSGVQGQ NWIVTNGLKA
361: GDKVIVDGVA KVKEGQEVSA KPYQAQPANS QGAAPNAAKP AQSGKPQAEQ KAASNA