2.A.6.1.12
NccABC Ni2+, Co2+, Cd2+ resistance efflux pump (Schmidt and Schlegel, 1994).
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| Accession Number: | Q44586 |
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| Protein Name: | Nickel-cobalt-cadmium resistance protein NccA |
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| Length: | 1076 |
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| Molecular Weight: | 115751.00 |
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| Species: | Alcaligenes xylosoxydans xylosoxydans [85698] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cadmium(2+), cobalt(2+), nickel(2+) |
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1: MIESILSGAV RFRWLVLFLT AVVGAIGAWQ LNLLPIDVTP DITNKQVQIN TVVPTLSPVE
61: VEKRVTYPIE TAIAGLNGVE NMRSLSRNGF SQVTVIFKES SNLYFMRQQV TERLAQARPN
121: LPAGVEPQMG PVSTGLGEVF HYSVEYEFPD GKGAKVKDGE PGWQSDGSFL TERGERLTDR
181: VSKLAYLRTV QDWIIRPQLR TTAGVADVDS LGGYVKQFVV EPDAAKMAAY GISFEELAQA
241: LEDANLSVGA NFIRRSGESY LVRADARIKS ADEIARAVIA QRQGVPITVG QVANINVGGE
301: LRSGAASRNG YETVVGSALM LVGANSRTVA QAVGDKLEEI KKTLPPGVVI VPTLNRSQLV
361: MATIKTVAKN LVEGAALVVV ILFALLGNWR AAVIAALVIP LSLLISAIGM NGLNISGNLM
421: SLGALDFGLI IDGAVIIVEN SLRRLAERQH HEGRLLTLKE RLEEVILSSR EMVRPTVYGQ
481: LVIFMVFLPC LTFQGVEGKM FSPMVITLML ALASAFVLSL TFVPAMVAVL LRKKVSEKEV
541: RVIAVTKERY RPLLERAVAR PMPFLGAALV TLALAAMAFT FVGREFMPTL DEQNLNLSSV
601: RIPSTSIDQS VAIDLPLERA VLSLPEVQTV YSKAGTASLA ADPMPPNASD NYIILKPKSE
661: WPEGITTKEQ VIERIREKTA PMVSNNYDVT QPIQMRFNEL IGGVRSDVAV KIYGENLDDL
721: ASTAQKIAAV LRKTPGATDT RVPLTGGFPT FDIVFDRAAI ARYGLTVKEV ADTVAAAMAG
781: RPSGQIFDGD RRYDIVIRLP GQQRENLDVL GALPVMLPAV EGQPRASVPL RQLVQFRFTQ
841: GLNEVSRDNG KRRVYVEANV GGRDLGSFVD DAAKRIAAEV KLPPGMYIEW GGQFQNLQAA
901: TQRLAIIVPL CFILIAATLY MAIGSAALTA TVLTAVPLAL AGGVFALVLR DIPFSISASV
961: GFIAVSGVAV LNGLVLISAI RKRLEDGAAP NEAVIEGAME RVRPVLMTAL VASLGFVPMA
1021: IATGTGAEVQ KPLATVVIGG LITATVLTLF VLPAVCGMVL RRQKKLEKPG GELLEA