2.A.6.2.35
Multidrug efflux pump, MexMN-OprM; exports chloramphenicol (Poole, 2008)
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| Accession Number: | Q4LDT8 |
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| Protein Name: | MexN |
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| Length: | 1036 |
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| Molecular Weight: | 110751.00 |
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| Species: | Pseudomonas aeruginosa GN=mexN PE=4 SV=1 [287] |
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| Number of TMSs: | 14 |
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| Location1 / Topology2 / Orientation3: |
Virion membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
chloramphenicol |
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| Pfam: |
PF00873
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[1] “Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa.” Mima T. et.al. 16301811
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1: MTPRAGISGW CVRHPIATAL LTLASLLLGL LAFLRLGVAP LPEADFPTIQ INALLPGGSP
61: ETMASSVATP LEVQFSAIPG ITEMTSSSAL GTTTLTLQFS LDKSIDVAAQ EVQAAINAAA
121: GRLPVDMPNL PTWRKVNPAD SPIMILRVNS EMMPLIELSD YAETILARQL SQVNGVGQIF
181: VVGQQRPAIR IQAQPEKLAA YQLTLADLRQ SLQSASVNLA KGALYGEGRV STLAANDQLF
241: NASDYDDLVV AYRQGAPVFL KDVARIVSAP EDDYVQAWPN GVPGVALVIL RQPGANIVDT
301: ADAIQAALPR LREMLPATIE VDVLNDRTRT IRSSLHEVEL TLLLTIGLVV LVMGLFLRQL
361: SATLIVATVL AVSLSASFAA MYVLGFTLNN LTLVALIIAV GFIVDDAIVV VENIHRHLEA
421: GASKVEAALK GAAEIGFTVI SISFSLIAAF IPLLFMGGIV GRLFREFAVS VTVAILISVV
481: ASLTLAPMLA SRFMPALRHA EAPRKGFAEW LTGGYERGLR WALGHQRLML VGFAFTVLVA
541: VAGYVGIPKG FFPLQDTAFV IGTSQAAEDI SYDDMVAKHR QLAEIIASDP AVQSYNHAVG
601: VTGGSQSLAN GRFWIVLKDR GERDVSVGEF IDRLRPQLAK VPGIMLYLRA AQDINLSSGP
661: SRTQYQYALR SSDSTQLALW AQRLTERLKQ VPGLMDVSND LQVGASVTAL DIDRVAAARF
721: GLSAEDVSQT LYDAFGQRQV GEYQTEVNQY KVVLELDARQ RGRAESLDWF YLRSPLSGEM
781: VPLSAIAKVA APRSGPLQIN HNGMFPAVNL SFNLAAGVSL GEAVQAVQRA QEEIGMPSTI
841: IGVFQGAAQA FQSSLASQPL LILAALIAVY IILGVLYESF VHPLTILSTL PSAGIGAVFL
901: LWAWGQDFSI MALIGIVLLI GIVKKNGILM VDFAIVAQRE QGMSAEQAIY QACLTRFRPI
961: MMTTLAALLG AIPLMIGFGT GSELRQPLGI AVVGGLLVSQ VLTLFSTPVV YLALERLFHR
1021: RGTTTSDGGT AGATAT