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3.D.4.4.3
The proton pumping Caa3-type cytochrome oxidase chains A-F. The crystal structure (PDB: 2YEV) is known (2.36Å resolution; Lyons et al., 2012). It has a covalently teathered cytochrome c domain. In the cytochrome aa3, O2 molecules that arrive at the reduction site diffuse through the X-ray-observed tunnel, supporting its role as the main O2 delivery pathway in this cytochrome ba3 as well as the cytochrome aa3 of Rhodobacter spheroides (Mahinthichaichan et al. 2018).

Accession Number:Q5SLI2
Protein Name:Cytochrome c oxidase subunit 2
Length:337
Molecular Weight:37351.00
Species:Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [300852]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

Entrez Gene ID: 3169690   
Pfam: PF00116    PF02790   
KEGG: ttj:TTHA0311   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0070469 C:respiratory chain
GO:0005507 F:copper ion binding
GO:0004129 F:cytochrome-c oxidase activity
GO:0009055 F:electron carrier activity
GO:0020037 F:heme binding
GO:0022904 P:respiratory electron transport chain
Structure:
2YEV     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MQRSFAALGL WGLSLAQEAH RVAITHPGGS FNQEVAFLFP WVYFFSFLIF LVVAGSLAYV 
61:	TWKFRARPED QEEPPQIHGN DRLEVVWTLI PLAIVFVLFG LTAKALIQVN RPIPGAMKVE 
121:	VTGYQFWWDF HYPELGLRNS NELVLPAGVP VELEITSKDV IHSFWVPGLA GKRDAIPGQT 
181:	TRISFEPKEP GLYYGFCAEL CGASHARMLF RVVVLPKEEF DRFVEAAKAS PAPVADERGQ 
241:	QVFQQNCAAC HGVARSMPPA VIGPELGLWG NRTSLGAGIV ENTPENLKAW IRDPAGMKPG 
301:	VKMPGFPQLS EEDLDALVRY LEGLKVEGFD FGALPKF