2.A.6.2.23
The multidrug (β-lactams, aminoglycerides (gentamycin and streptomycin) macrolides (erythromycin) and dye (acriflavin)) efflux pump, BpeAB-OprB (Chan et al., 2004; Chan and Chua, 2005). It also exports acyl homoserine lactones including N-octanoyl-homoserine lactone, N-decanoyl-homoserine lactone, N-(3-hydroxy)-octanoyl-homoserine lactone, N-(3-hydroxy)-decanoyl-homoserine lactone, N-(3-oxo)-decanoyl-homoserine lactone, and N-(3-oxo)-tetradecanoyl-homoserine lactone (Chan et al., 2007). Q9HWH6 is a DoxX family member (see 9.B.214.2).
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| Accession Number: | Q6VV69 |
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| Protein Name: | BpeA |
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| Length: | 402 |
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| Molecular Weight: | 41933.00 |
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| Species: | Burkholderia pseudomallei (Pseudomonas pseudomallei) [28450] |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
beta-lactam, streptomycin, gentamycin, erythromycin A, 3,6-diamino-10-methylacridinium chloride, N-acyl homoserine lactone |
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| Pfam: |
PF00529
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[1] “BpeAB-OprB, a multidrug efflux pump in Burkholderia pseudomallei.” Chan Y.Y. et.al. 15047512
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1: MRVERVPYRL ITVATAAVFL AACGKKESAP PPQTPEVGVV TVQPQPVPVV SELPGRTSAY
61: LVAQVRARVD GIVLRREFTE GSDVKAGQRL YKIDPAPYIA QLNSAKATLA KAQANLATQN
121: ALVARYKVLV AANAVSKQQY DDAVAAQGQA AADVGAGKAA VETAQINLGY TDVVSPITGR
181: VGISQVTPGA YVQASQATLM STVQQLDPVY VDLTQSSLDG LKLRQDIQSG RIKTEGPGAA
241: KVTLILEDGK PYPERGKLQF SDVTVDQTTG SVTIRAIFPN KQRVLLPGMF VRARIEEGVN
301: ENAFLIPQIG VTHDPKGQAI AMIVDGKGKV EPRVLVTGGT QGQNWVVESG LQAGDRVIVQ
361: GIDKVRPGMT VKAAEAQLPA AAASAAASGA APSSAAAASS AQ