TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.25.8
An ECF ABC transporter with 4 subunits, EcfS/EcfT/EcfA/EcfA'.  EcfS is also called RibU; EcfT is also called CbiQ, EcfA is also called Cbi01, and EcfA' is also called Cbi02.  This system can take up riboflavin and possibly other vitamins (Karpowich et al. 2015). ATP binding to the EcfAA' ATPases drives a conformational change that dissociates the S subunit from the EcfAA'T ECF module. Upon release from the ECF module, the RibU S subunit then binds the riboflavin transport substrate.  S subunits for distinct substrates compete for the ATP-bound state of the ECF module (Karpowich et al. 2015). RibU appears to be capable of exporting riboflavin, FMN and FAD (Light et al. 2018).

Accession Number:Q71WH7
Protein Name:Energy-coupling factor transporter ATP-binding protein EcfA1
Length:279
Molecular Weight:30870.00
Species:Listeria monocytogenes serotype 4b (strain F2365) [265669]
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2
Substrate FMN, FAD, riboflavin

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MAESFVRLEH VFYKYEDTEK YAVKDVSISA QKGEWVALVG HNGSGKSTIA KLLNGLLFPE 
61:	DGLIKIGHFV LSEKNIWDIR RQVGMVFQNP DNQFVGATVQ DDVAFGLENH GVPHDTMVER 
121:	VESALNEVGM QSYALHEPAR LSGGQKQRVA IAGVLALQPD VIILDEATSM LDPRGRAEVM 
181:	ETIRIMREQE DITVISITHD LDEVLFADRV IVMNNGEVHS EGTPQEIFEQ ADAMREIGLG 
241:	VPFIIELQEK LVAGGFETGS TVLSEGALLD QLWKLNSNN