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3.D.1.5.1
Proton-translocating NADH dehydrogenase I.  NDUFS4 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  However, a knockout of NDUFS4 in human iPSCs provides a model for mitochondrial complex I deficiencyin humans (Goolab et al. 2025).

Accession Number:Q746T2
Protein Name:NuoH aka GSU3436
Length:329
Molecular Weight:36087.00
Species:Geobacter sulfurreducens [35554]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

RefSeq: NP_954476.1   
Entrez Gene ID: 2686874   
Pfam: PF00146   
BioCyc: GSUL243231:GSU_3436-MONOMER   
KEGG: gsu:GSU3436   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0050136 F:NADH dehydrogenase (quinone) activity
GO:0048038 F:quinone binding
GO:0055114 P:oxidation reduction

References (1)

[1] “Genome of Geobacter sulfurreducens: metal reduction in subsurface environments.”  Methe B.A.et.al.   14671304

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNGVALDIAI HGAKIALIFF VVLTLAAYLV FAERRLLAWI QDRKGPNRVG PFGLLQPLAD 
61:	LIKLLTKEDF RPAGADKWLF YLAPAMAAVP AILTFAVIPF GAPVTILGRE IPLQVADLNV 
121:	GLLFFLALSS IAVYGVALGG WASNSKYALL GSIRGLAQLI SYELSMGLSL VPTVMLAGSL 
181:	RLSDIVAAQE GVWFIAYQPV AFLIFLISIA AECKRIPFDI PEAEGELVAG FHTEYSGMRF 
241:	GLFFVGEYIN IIVLGGLATT FFLGGWQGPL LPPFVWFSVK TLAFAFFFIW MRGTLPRLRY 
301:	DQLMHLGWKV LTPLALLNIL ITGWVLMFV