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3.D.1.5.1
Proton-translocating NADH dehydrogenase I.  NDUFS4 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  However, a knockout of NDUFS4 in human iPSCs provides a model for mitochondrial complex I deficiencyin humans (Goolab et al. 2025).

Accession Number:Q746T8
Protein Name:NuoM aka GSU3430
Length:496
Molecular Weight:53771.00
Species:Geobacter sulfurreducens [35554]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

RefSeq: NP_954470.1   
Entrez Gene ID: 2686865   
Pfam: PF00361   
BioCyc: GSUL243231:GSU_3430-MONOMER   
KEGG: gsu:GSU3430   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008137 F:NADH dehydrogenase (ubiquinone) activity
GO:0042773 P:ATP synthesis coupled electron transport

References (1)

[1] “Genome of Geobacter sulfurreducens: metal reduction in subsurface environments.”  Methe B.A.et.al.   14671304

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MTSYSILTIL ILLPLAGCFC LAPVWNRPEW ARPLALGIAV AELALAGWVL VAAPGMPPAP 
61:	GAAAGYFLWE DAAWIERFGI RYLLGMDGIS LLMVALTAFT TVVAMLVSWR GITERATLHY 
121:	FLILLMESGI MGVFLSLDLV LFYLFWEVML IPMFFLIGIW GHGRRIYSAV KFFLYTLVGS 
181:	LLMLLAIIGV YLIHGDATGT FTFALPLLAK SPIAHAAAPW LFGAFLLAFA IKFPLFPVHT 
241:	WLPDAHTDAP TAGSVILAAL LLKTGAYGLV RFGYPLFPEA AKGFTPLLYV LAIIGILYAS 
301:	WIAYAQEDMK RMVAYSSVGH MGFVALGIAS WGPVALSGSI LQMVNHGFTT AALFALVGML 
361:	DERAHTREVS AFGGLWGTMP AFSFFFLFFA MASAGLPGLN NFVGEFLILV GVFRITPAAG 
421:	AIAFLGIVLP LIYTVRLVQE VLFQTERRPL RLPDLTLREG AVLAVLAVID LYIGVHPKPL 
481:	LDILKVPVAL LTGVAP