1.B.14.5.1 HasR receptor-HasA haemophore heme receptor complex (HasA, an extracellular heme binding protein, binds one heme and transfers it directly to HasR, which uses HasB (2.C.1.1.2) (a TonB homologue) instead of TonB (2.C.1.1.1) for energization) (Benevides-Matos et al., 2008; Izadi-Pruneyre et al., 2006; Lefèvre et al., 2008; Benevides-Matos and Biville, 2010). A signaling domain in HasR interacts with a partially unfolded periplasmic domain of an antisigma factor, HasS, to control transcription by an ECF sigma factor (Malki et al. 2014). The
HasR domain responsible for signal transfer is highly flexible in two stages of signaling,
extends into the periplasm at about 70 to 90 A from the HasR beta-barrel and exhibits local
conformational changes in response to the arrival of signaling activators (Wojtowicz et al. 2016). Studies revealed a previously unidentified network of HasR-HasB protein-protein interactions in the periplasm (Somboon et al. 2024).
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Accession Number: | Q79AD2 |
Protein Name: | HasR protein |
Length: | 899 |
Molecular Weight: | 98281.00 |
Species: | Serratia marcescens [615] |
Location1 / Topology2 / Orientation3: |
Cell outer membrane1 |
Substrate |
ferroheme b |
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1: MFIHKGTTPA GRLATAVRAA LAAMMLTQPA VALAAQAEAS SAQAAQQKNF NIAAQPLQSA
61: MLRFAEQAGM QVFFDEVKLD GMQAAALNGS MSVEQGLRRL IGGNPVAFRL QPQGQIVLSR
121: LPTANGDGGA LALDSLTVLG AGGNNANDWV YDEPRSVSVI SREQMDNRPA RHAADILEQT
181: TGAYSSVSQQ DPALSVNIRG IQDYGRVNMN IDGMRQNFQK SGHGQRNGTM YIDSELLSGV
241: TIDKGTTGGM GSAGTLGGIA TFNTVSASDF LAPGKELGGK LHASTGDNGT HFIGSGILAL
301: GNETGDILLA ASERHLGDYW PGNKGDIGNI RINNDTGNYD RYAESIKNNK IPDTHYRMHS
361: RLAKVGWNLP ANQRLQLSYL QTQTASPIAG TLTNLGTRPP YELGWKRTGY TDVMARNAAF
421: DYSLAPEDVD WLDFQAKLYY VDTQDDSDTY STSSLLDNGY ATRTRLRTYG AQAQNTSRFS
481: LAPGHDFRAN YGLEFYYDKA TSDSSRQGME GVTPAGNRSV ASLFANLTYD YDGWLTLEGG
541: LRYDRYRLRG QTGLSYPDLA KDGQRYTIDN PCKALRLTGC STTTREDWDV DRDQGKLSPT
601: LAVAVRPGVE WLELYTTYGK SWRPPAITET LTNGSAHSSS TQYPNPFLQP ERSRAWEVGF
661: NVQQPDLWFE GDRLVAKVGY FDTKVDNYIN LAIDRNKPGL VQPSIGNAAY VNNLSKTRFR
721: GLEYQLNYDA GVFYADLTYT HMIGKNEFCS NKAWLGGRLR YGDGSRRGNF YVEPDAASND
781: FVTCDGGTQF GSAAYLPGDR GSVTLGGRAF DRKLDAGVTV RFAPGYQDSS VPSNYPYLAD
841: WPKYTLFDLY ASYKLTDSLT LRGSVENLTN RAYVVSYGET LANTLGRGRT VQGGVEYRF