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1.B.14.5.1
HasR receptor-HasA haemophore heme receptor complex (HasA, an extracellular heme binding protein, binds one heme and transfers it directly to HasR, which uses HasB (2.C.1.1.2) (a TonB homologue) instead of TonB (2.C.1.1.1) for energization) (Benevides-Matos et al., 2008; Izadi-Pruneyre et al., 2006; Lefèvre et al., 2008; Benevides-Matos and Biville, 2010). A signaling domain in HasR interacts with a partially unfolded periplasmic domain of an antisigma factor, HasS, to control transcription by an ECF sigma factor (Malki et al. 2014).  The HasR domain responsible for signal transfer is highly flexible in two stages of signaling, extends into the periplasm at about 70 to 90 A from the HasR beta-barrel and exhibits local conformational changes in response to the arrival of signaling activators (Wojtowicz et al. 2016).

Accession Number:Q79AD2
Protein Name:HasR protein
Length:899
Molecular Weight:98281.00
Species:Serratia marcescens [615]
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate ferroheme b

Cross database links:

Structure:
3CSL   3CSN   3DDR   2M5J   5C58     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFIHKGTTPA GRLATAVRAA LAAMMLTQPA VALAAQAEAS SAQAAQQKNF NIAAQPLQSA 
61:	MLRFAEQAGM QVFFDEVKLD GMQAAALNGS MSVEQGLRRL IGGNPVAFRL QPQGQIVLSR 
121:	LPTANGDGGA LALDSLTVLG AGGNNANDWV YDEPRSVSVI SREQMDNRPA RHAADILEQT 
181:	TGAYSSVSQQ DPALSVNIRG IQDYGRVNMN IDGMRQNFQK SGHGQRNGTM YIDSELLSGV 
241:	TIDKGTTGGM GSAGTLGGIA TFNTVSASDF LAPGKELGGK LHASTGDNGT HFIGSGILAL 
301:	GNETGDILLA ASERHLGDYW PGNKGDIGNI RINNDTGNYD RYAESIKNNK IPDTHYRMHS 
361:	RLAKVGWNLP ANQRLQLSYL QTQTASPIAG TLTNLGTRPP YELGWKRTGY TDVMARNAAF 
421:	DYSLAPEDVD WLDFQAKLYY VDTQDDSDTY STSSLLDNGY ATRTRLRTYG AQAQNTSRFS 
481:	LAPGHDFRAN YGLEFYYDKA TSDSSRQGME GVTPAGNRSV ASLFANLTYD YDGWLTLEGG 
541:	LRYDRYRLRG QTGLSYPDLA KDGQRYTIDN PCKALRLTGC STTTREDWDV DRDQGKLSPT 
601:	LAVAVRPGVE WLELYTTYGK SWRPPAITET LTNGSAHSSS TQYPNPFLQP ERSRAWEVGF 
661:	NVQQPDLWFE GDRLVAKVGY FDTKVDNYIN LAIDRNKPGL VQPSIGNAAY VNNLSKTRFR 
721:	GLEYQLNYDA GVFYADLTYT HMIGKNEFCS NKAWLGGRLR YGDGSRRGNF YVEPDAASND 
781:	FVTCDGGTQF GSAAYLPGDR GSVTLGGRAF DRKLDAGVTV RFAPGYQDSS VPSNYPYLAD 
841:	WPKYTLFDLY ASYKLTDSLT LRGSVENLTN RAYVVSYGET LANTLGRGRT VQGGVEYRF