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3.A.1.12.13 High affinity (2mμM) choline uptake porter. The choline binding receptor exhibits a venus fly trap mechanism of substrate binding. (ChoX binds acetyl choline and betaine with low affinity (80μM and 470μM, respectively) (Aktas et al., 2011) (most similar to 3.A.1.12.7)
Accession Number:	Q7CXG1
Protein Name:	ABC transporter, membrane spanning protein (Proline/glycine betaine)
Length:	343
Molecular Weight:	37283.00
Species:	Agrobacterium tumefaciens (strain C58 / ATCC 33970) [176299]
Number of TMSs:	8
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	choline

Entrez Gene ID:	1134318
Pfam:	PF00528
KEGG:	atu:Atu2280
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0005215 F:transporter activity
References (2) [1] “Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58.” Goodner B.et.al. 11743194 [2] “The genome of the natural genetic engineer Agrobacterium tumefaciens C58.” Wood D.W.et.al. 11743193

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MDLHRARQRR CRPSLLYWSN SGDNRSLKKL RFFVVCAIPD AKPLCIFAGI ALIHERSFLT 
61:	VEWLSAPENR LPIGRYAKEA IDWLTGNLAF FFDWLSFIFQ SVINALLYVL QAPHPLIIVA 
121:	IVTALSAWTR RSAGMPIFTA LGLLLIINLG YWKATTETLA LVIAASAVCM IIGIPLGILA 
181:	ARRKWIYAGM RPALDLMQTI PTFVYLIPAL VLFGLGMVPG LIATVIFAIP APVRLTRLGI 
241:	VSTPPALVEA AVAFGATPSQ VLRKVELPFA APQIMAGLTQ TIMLSLSMVV ISALVGANGL 
301:	GVPVVRALNT VNIAMGFEAG LCIVILAIVL DRLFRLPGTE DDL

3.A.1.12.13
High affinity (2mμM) choline uptake porter. The choline binding receptor exhibits a venus fly trap mechanism of substrate binding. (ChoX binds acetyl choline and betaine with low affinity (80μM and 470μM, respectively) (Aktas et al., 2011) (most similar to 3.A.1.12.7)

Cross database links:

Gene Ontology

References (2)

External Searches:

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3.A.1.12.13High affinity (2mμM) choline uptake porter. The choline binding receptor exhibits a venus fly trap mechanism of substrate binding. (ChoX binds acetyl choline and betaine with low affinity (80μM and 470μM, respectively) (Aktas et al., 2011) (most similar to 3.A.1.12.7)

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

3.A.1.12.13
High affinity (2mμM) choline uptake porter. The choline binding receptor exhibits a venus fly trap mechanism of substrate binding. (ChoX binds acetyl choline and betaine with low affinity (80μM and 470μM, respectively) (Aktas et al., 2011) (most similar to 3.A.1.12.7)