3.A.1.135.9
Multidrug exporter, EfrEF. Mediates efflux of fluorescent substrates and confers resistance towards multiple dyes and drugs including fluoroquinolones (Hürlimann et al. 2016).
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| Accession Number: | Q832K0 |
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| Protein Name: | ABC transporter, ATP-binding/permease protein |
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| Length: | 575 |
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| Molecular Weight: | 63400.00 |
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| Species: | Enterococcus faecalis (strain ATCC 700802 / V583) [226185] |
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| Number of TMSs: | 5 |
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| Substrate |
fluoroquinolone antibiotic, drug |
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1: MKLMKEFIKE NKWIVLATTL TICLQIAGTL GVPKLVGKLI DVGIVSGDQQ VIKTIGIQMF
61: LVAFIGTIAA IISSYLSALV AAKFGFQVRG LFFKKFQQFS MKNVDKFGSN SLLTRMTNDV
121: DNVQTMIVLF CQLIFPAPII SLFALVMTFS YSVSLAWVTL ASIVFYLVVV YFLMKKGTPL
181: SLKIQPKMDR ITTTLREFFT GINMIRAFNN QDFEEQRTNQ TFKNYAERMS KVNQIFAWIT
241: PVAFLLMGVV YASILWFGGN LVAVGTLQIG TVTAVIEYTL LTLAYLMIAA MVLVVIPRSV
301: ASLNRLQEVL SEEIEISDPH TEATIAYHPE KALICFDHVT FQYTETADPV LENVSFVIPK
361: GKTTAIVGAT GAGKSTLVKL LLRINEVTAG TISYSGTDIR SLSQQTIRQV ISYVPQKAFL
421: FSGTILSNLL MGNAKATTEE IRTALEISQS SEFIDSLPQG IESFVAQGGS NYSGGQKQRM
481: CIARALIKPA DVYIFDDSFS ALDYKTDAAL RAALHAQMSD KTLLIVAQRL STIMNADNII
541: VLDEGRIVGQ GTHADLLTTN SYYQDFAKSQ GILPK