2.A.6.2.19
The multidrug efflux pump, EefABC (exports chloramphenicol, ciprofloxacin, erythromycin, tetracycline and doxycycline) (Masi et al., 2005). EefC exhibits low ionic selectivity (Masi et al., 2007).
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| Accession Number: | Q8GC83 |
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| Protein Name: | EefB inner membrane protein |
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| Length: | 1035 |
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| Molecular Weight: | 110852.00 |
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| Species: | Enterobacter aerogenes (Aerobacter aerogenes) [548] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ion, ciprofloxacin, chloramphenicol, tetracycline, doxycycline, erythromycin A |
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| Pfam: |
PF00873
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[1] “The eefABC multidrug efflux pump operon is repressed by H-NS in Enterobacter aerogenes.” Masi M. et.al. 15901719
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1: MFSRFFVRRP VFAWVIAILI MLAGALAIRT LPVGQYPDVA PPAVKISATY TGASAETLEN
61: SVTQVIEQQL TGLDNLLYFT STSSSDGTVS ITVTFEQGTD PDTAQVQVQN KVQQAESRLP
121: SEVQQSGVTV EKSQSSFLLI LAVYDKTNRA TSSDISDWLV SNMQDPLARV EGVGSLQVFG
181: AEYAMRIWMD PTKLASYSLM PSDVQSAIEA QNVQVSAGKI GALPSSNTQQ LTATVRAQSR
241: LQTPDQFKAI IVKSQSDGSV VRLSDVARVE MGSEDYTATA NLNGHPAAGI AVMMAPGANA
301: LDTATLVKSK IAEFQRQMPQ GYDIAYPKDS TEFIKISVED VIQTLFEAII LVVCVMYLFL
361: QNFRATLIPA VAVPVVLLGT FGVLALFGYS INTLTLFAMV LAIGLLVDDA IVVVENVERI
421: MRDEALPARE ATEKSMGEIS GALVAIALVL SAVFLPMAFF GGSTGVIYRQ FSVTIISAMM
481: LSVVVALTLT PALCGALLSH SKPHDKGFFG AFNRLWGRTE DGYQRRVLGG LRRGAVMMGA
541: YALICGAMAL AMWKLPGSFL PVEDQGEIMV QYTLPAGATA VRTAEVRRQV TDWFLTKEKA
601: NTEVIFTVDG FSFSGSGQNA GMAFVSLKNW SQRKGDENTA QAIALRANKE LGAIRDATLF
661: AMTPPSVDGL GQSNGFTFEL MASGGTDRDS LMKLRSQLLA AANQSGELQS VRANDLPQMP
721: QLQVDIDNNK AVSLGLSLSD VTDTLSSAWG GTYVNDFIDR GRVKKVYIQG ESDARAVPSD
781: LGKWFVRASD NSMTPFTAFA TTHWEYGPES LVRYNGSAAF EIQGENAAGF SSGAAMDKME
841: KLADSLPAGS TWAWSGISLQ EKLASGQAMS LYAISILVVF LCLAALYESW SVPFSVIMVI
901: PLGLLGAALA ATLRGLSNDV YFQVALLTTI GLSSKNAILI VEFAESAVDE GYSLSRAAIR
961: AAQTRLRPIV MTSLAFIAGV LPLAIATGAG ANSRVAIGTG IIGGTLTATL LAVFFVPLFF
1021: VLVKRLFTRP RPSQE