3.A.7.15.1
The nonspecific tight adherence fibril (pilus) secretion septum (Flp-1, Flp-2, TadV-RcpCAB Tad ZA-G) (Kachlany et al., 2000; Bhattacharjee et al., 2001; Haase et al., 2003; Schreiner et al., 2003; Wang and Chen, 2005; Tomich et al. 2007). The outer membrane components of the Tad (tight adherence) secreton have been identified (Clock et al. 2008). The tad locus is required for tenacious, nonspecific adherence to surfaces and
formation of extremely strong biofilms. This locus is dedicated to the
biogenesis of Flp pili, which are required for colonization and
virulence (Perez et al. 2006). The formation of biofilms enhances gastrointestinal tolerance and
intestinal adhesion of probiotics, presenting great applied potential in
increasing the efficacy of probiotics (Gao et al. 2025).
|
| Accession Number: | Q8GCZ9 |
|---|
| Protein Name: | TadZ |
|---|
| Length: | 374 |
|---|
| Molecular Weight: | 41681.00 |
|---|
| Species: | Actinobacillus actinomycetemcomitans (Haemophilus actinomycetemcomitans) [714] |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
protein polypeptide chain |
|---|
[1] “Genes for tight adherence of Actinobacillus actinomycetemcomitans: from plaque to plague to pond scum.” Kachlany S.C. et.al. 11553455
[2] “The Widespread Colonization Island of Actinobacillus actinomycetemcomitans.” Planet P.J. et.al. 12717435
|
1: MLLLDQETIT ADSARTITIV SSRDDIQGEV AQILRTRGLE NIEIVKKDFF TSSDEISFSA
61: EDTVGVIIDI THETNIKTIV ERVFSIVPQN VWCCVIGDSD SISLSQKLLD EGILYFNSHT
121: QLSQMVEKII LGVDIPRLRD TVKIAVLSCK GGIGASLISS HIANEIVSSK KIPVLLAQGP
181: NGSQDLDLLF DKKLSGNVIE YTPNLDIFNG SLFELTPAAT EKYNFIIYDQ PIYNVKKDNF
241: IGFLENYNSF VLVVERRIGS LRLAKQFLDE CERIRSTSRK PIRTFVCISD NRMESAKLMA
301: KNDIETLIGS SIDAVIPYIK NTNTKTVLGI NLGRDGKKEI NSLMLKVIGA ISRSSKPKEK
361: QSLFSSFFSK LIKQ