2.A.6.2.4
The multidrug resistance pump, AdeDE (exports amikacin, ceftazidime, chloramphenicol, ciprofloxacin, erythromycin, ethidium bromide, meropenem, rifampin, and tetracycline) (Chau et al., 2004).
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| Accession Number: | Q8GKU1 |
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| Protein Name: | AdeE |
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| Length: | 1036 |
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| Molecular Weight: | 111323.00 |
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| Species: | Acinetobacter sp. 4365 [209657] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
rifampicin, ciprofloxacin, chloramphenicol, tetracycline, erythromycin A, ethidium bromide, amikacin, ceftazidime, meropenem |
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| Pfam: |
PF00873
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[1] “Novel resistance-nodulation-cell division efflux system AdeDE in Acinetobacter genomic DNA group 3.” Chau S.L. et.al. 15388479
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1: MLSSFFIARP IFAWVLSICI MALGTISILT LPIEQYPDIA PPGVNVTANY PGASAKTVED
61: SVTQILEQQI KGIDGLLYFS SSSSSAGQAR ISLSFDQNTN PDTAQVQVQN AVNQALSRLP
121: QEVQQQGITV TKSQGDSLLV FALYDESGTR SSVDISDYMV STLQDPLSRV DGVGEITAFG
181: AQYAMRIWLD PHKLNSYGLM PSDVRTAIEA QNTQITAGEL GALPTRDGQA LNATVTALSR
241: LQTVSQFENI ILRTETNGAV VLLKDVARVE RGAESYQTST RLNGKPASGM SIQLASGANA
301: LETAERVKAE VTRLTASMPA GLKVAYPRDS TPFVEASVNG VIKTLAEAIV LVIIVMFLFL
361: QSWRATLIPA IAVPVVLLGT FGVLSVLGYS INTLTLFAMV LAIGLLVDDA IVVVENVERV
421: MHEQNLDARQ ATLISMQEIS GALVGIAMVL AAVFLPMAFF GGSVGIIYRQ FSVTLVSAMV
481: LSAIVALTLS PALCATLLKP ANEKHKQRKF FTWFNRKVEQ GQSGYRTKLV AVLGKPKVFM
541: IIFVGITALL GWQYTRMNTG FLPQEDQGSV MVQFSTPVGT TLAETERVGN QIADYFLTKE
601: KNNLNVIFMV MGRNNAGSGQ NVGMAFAGLK HWDDREGSEN TAEAVIARAN AHFKSLRNAR
661: VQVLSPAAVR GLGQSSGFEF WLQDAENKGR DALLAAQNNV LKANADSGLA AVRLNSLEDK
721: AQLQVDIDQR KASALGLAQA DISNTLSSAW GGSYINDFID QGRVKRVYLQ GEANYRSLPQ
781: DIGQWYVRGT SGEMTPFSSF SSVKWQMGPQ MLQRFNGLSA VQIQGSAAAG ESSGGAMDKM
841: QQLVDQQQGF NLQWSGLSYQ EKLAGGQTIW LYLASIIFIF LCLAALYESW SIPVSVMLVI
901: PLGLIGAVVA ASLAGFVNDI YFQVAMLTTI GLSAKNAILI VEFAAAKLEA GQALMDAIIE
961: GAGQRLRPII MTSLAFVAGV LPLAVSTGAG AVSRKEIGIA VTGGMISGTL LSIFFVPLFF
1021: LLVRRLTNKL NTKKAK