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1.A.10.1.10
The homo- and heteromeric glutamate receptor, GLR3.3/3.4 (Desensitized in 3 patterns: (1) by Glu alone; (2) by Ala, Cys, Glu or Gly; (3) by Ala, Cys, Glu, Gly, Ser or Asn (Stephens et al., 2008). A regulatory mechanism underlies Ca2+ homeostasis by sorting and activation of AtGLRs by AtCNIHs (see for example, 8.A.61.1.9) (Wudick et al. 2018).  May be responsible in part for Cd2+ uptake (Chen et al. 2018). GLR3.3 and GLC3.6 (TC# 1.A.10.1.24) (but not GLR3.4) play different roles in nervous system-like signaling in plant defense by a mechanism that differs substantially from that in animals (Toyota et al. 2018). Members of the banana GLR gene family have been identified, and expression analyses in response to low temperature and abscisic acid/methyl jasmonate concentrations have been reported (Luo et al. 2023).  Phosphatidylinositol-specific phospholipase C-associated phospholipid metabolism mediates the DcGLRs channel to promote calcium influx under CaCl2 treatment in shredded carrots during storage (Zhang et al. 2024).

Accession Number:Q8GXJ4
Protein Name:GLR3.4
Length:959
Molecular Weight:107207.00
Species:Arabidopsis thaliana [3702]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ion, calcium ion

Cross database links:

RefSeq: NP_001030971.1    NP_172012.2   
Entrez Gene ID: 839268   
Pfam: PF01094    PF00060    PF00497   
KEGG: ath:AT1G05200   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0030288 C:outer membrane-bounded periplasmic space
GO:0005234 F:extracellular-glutamate-gated ion channel a...
GO:0004965 F:GABA-B receptor activity
GO:0004970 F:ionotropic glutamate receptor activity
GO:0005515 F:protein binding
GO:0007186 P:G-protein coupled receptor protein signalin...
GO:0006811 P:ion transport

References (3)

[1] “Phylogenetic and expression analysis of the glutamate-receptor-like gene family in Arabidopsis thaliana.”  Chiu J.C.et.al.   12082126
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Functional annotation of a full-length Arabidopsis cDNA collection.”  Seki M.et.al.   11910074

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGFLVMIREV SMAKAIRVVL LCVSVLWVVP KECACRSNFS RNSSSSSSSS LRPLRQRPSS 
61:	VNVGALFTYD SFIGRAAKPA VKAAMDDVNA DQSVLKGIKL NIIFQDSNCS GFIGTMGALQ 
121:	LMENKVVAAI GPQSSGIAHM ISYVANELHV PLLSFGATDP TLSSLQFPYF LRTTQNDYFQ 
181:	MHAIADFLSY SGWRQVIAIF VDDECGRNGI SVLGDVLAKK RSRISYKAAI TPGADSSSIR 
241:	DLLVSVNLME SRVFVVHVNP DSGLNVFSVA KSLGMMASGY VWIATDWLPT AMDSMEHVDS 
301:	DTMDLLQGVV AFRHYTIESS VKRQFMARWK NLRPNDGFNS YAMYAYDSVW LVARALDVFF 
361:	RENNNITFSN DPNLHKTNGS TIQLSALSVF NEGEKFMKII LGMNHTGVTG PIQFDSDRNR 
421:	VNPAYEVLNL EGTAPRTVGY WSNHSGLSVV HPETLYSRPP NTSTANQRLK GIIYPGEVTK 
481:	PPRGWVFPNN GKPLRIGVPN RVSYTDYVSK DKNPPGVRGY CIDVFEAAIE LLPYPVPRTY 
541:	ILYGDGKRNP SYDNLVNEVV ADNFDVAVGD ITIVTNRTRY VDFTQPFIES GLVVVAPVKE 
601:	AKSSPWSFLK PFTIEMWAVT GGFFLFVGAM VWILEHRFNQ EFRGPPRRQL ITIFWFSFST 
661:	MFFSHRENTV SSLGRFVLII WLFVVLIINS SYTASLTSIL TIRQLTSRIE GIDSLVTSNE 
721:	PIGVQDGTFA RNYLINELNI LPSRIVPLKD EEQYLSALQR GPNAGGVAAI VDELPYIEVL 
781:	LTNSNCKFRT VGQEFTRTGW GFAFQRDSPL AVDMSTAILQ LSEEGELEKI HRKWLNYKHE 
841:	CSMQISNSED SQLSLKSFWG LFLICGITCF MALTVFFWRV FWQYQRLLPE SADEERAGEV 
901:	SEPSRSGRGS RAPSFKELIK VVDKREAEIK EILKQKSSKK LKSTQSAAGT SQSQHGEIT