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1.A.10.1.10
The homo- and heteromeric glutamate receptor, GLR3.3/3.4 (Desensitized in 3 patterns: (1) by Glu alone; (2) by Ala, Cys, Glu or Gly; (3) by Ala, Cys, Glu, Gly, Ser or Asn (Stephens et al., 2008). A regulatory mechanism underlies Ca2+ homeostasis by sorting and activation of AtGLRs by AtCNIHs (see for example, 8.A.61.1.9) (Wudick et al. 2018).  May be responsible in part for Cd2+ uptake (Chen et al. 2018). GLR3.3 and GLC3.6 (TC# 1.A.10.1.24) (but not GLR3.4) play different roles in nervous system-like signaling in plant defense by a mechanism that differs substantially from that in animals (Toyota et al. 2018).

Accession Number:Q8GXJ4
Protein Name:GLR3.4
Length:959
Molecular Weight:107207.00
Species:Arabidopsis thaliana [3702]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ion, calcium ion

Cross database links:

RefSeq: NP_001030971.1    NP_172012.2   
Entrez Gene ID: 839268   
Pfam: PF01094    PF00060    PF00497   
KEGG: ath:AT1G05200   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0030288 C:outer membrane-bounded periplasmic space
GO:0005234 F:extracellular-glutamate-gated ion channel a...
GO:0004965 F:GABA-B receptor activity
GO:0004970 F:ionotropic glutamate receptor activity
GO:0005515 F:protein binding
GO:0007186 P:G-protein coupled receptor protein signalin...
GO:0006811 P:ion transport

References (3)

[1] “Phylogenetic and expression analysis of the glutamate-receptor-like gene family in Arabidopsis thaliana.”  Chiu J.C.et.al.   12082126
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Functional annotation of a full-length Arabidopsis cDNA collection.”  Seki M.et.al.   11910074

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGFLVMIREV SMAKAIRVVL LCVSVLWVVP KECACRSNFS RNSSSSSSSS LRPLRQRPSS 
61:	VNVGALFTYD SFIGRAAKPA VKAAMDDVNA DQSVLKGIKL NIIFQDSNCS GFIGTMGALQ 
121:	LMENKVVAAI GPQSSGIAHM ISYVANELHV PLLSFGATDP TLSSLQFPYF LRTTQNDYFQ 
181:	MHAIADFLSY SGWRQVIAIF VDDECGRNGI SVLGDVLAKK RSRISYKAAI TPGADSSSIR 
241:	DLLVSVNLME SRVFVVHVNP DSGLNVFSVA KSLGMMASGY VWIATDWLPT AMDSMEHVDS 
301:	DTMDLLQGVV AFRHYTIESS VKRQFMARWK NLRPNDGFNS YAMYAYDSVW LVARALDVFF 
361:	RENNNITFSN DPNLHKTNGS TIQLSALSVF NEGEKFMKII LGMNHTGVTG PIQFDSDRNR 
421:	VNPAYEVLNL EGTAPRTVGY WSNHSGLSVV HPETLYSRPP NTSTANQRLK GIIYPGEVTK 
481:	PPRGWVFPNN GKPLRIGVPN RVSYTDYVSK DKNPPGVRGY CIDVFEAAIE LLPYPVPRTY 
541:	ILYGDGKRNP SYDNLVNEVV ADNFDVAVGD ITIVTNRTRY VDFTQPFIES GLVVVAPVKE 
601:	AKSSPWSFLK PFTIEMWAVT GGFFLFVGAM VWILEHRFNQ EFRGPPRRQL ITIFWFSFST 
661:	MFFSHRENTV SSLGRFVLII WLFVVLIINS SYTASLTSIL TIRQLTSRIE GIDSLVTSNE 
721:	PIGVQDGTFA RNYLINELNI LPSRIVPLKD EEQYLSALQR GPNAGGVAAI VDELPYIEVL 
781:	LTNSNCKFRT VGQEFTRTGW GFAFQRDSPL AVDMSTAILQ LSEEGELEKI HRKWLNYKHE 
841:	CSMQISNSED SQLSLKSFWG LFLICGITCF MALTVFFWRV FWQYQRLLPE SADEERAGEV 
901:	SEPSRSGRGS RAPSFKELIK VVDKREAEIK EILKQKSSKK LKSTQSAAGT SQSQHGEIT