3.A.2.2.10
13 component V-type ATPase of Plasmodium falciparum. (1) VapA (V1 subunit A; 611 aas), (2) VapB (V1 subunit B; 494 aas), (3) VapC (V1 subunit C; 383 aas), (4) V1 subunit D; 347 aas), (5) VapE (V1 subunit E; 235 aas), (6) VapF (V1 subunit F; 128 aas), (7) VapG (V1 subunit G; 123 aas) (8) VapH; V1 subunit; 455 aas), (9) Vo subunit a; 299 aas), (10) Vo subunit c; 165 aas), (11) Vo subunit C*; 181 aas), (12) Vo subunit d; 382 aas), (13) Vo subunit e; 78 aas). The system is involved in the active export of H+ from the cytoplasm (Wunderlich 2022).
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| Accession Number: | Q8IAQ8 |
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| Protein Name: | V-type proton ATPase subunit a, putative |
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| Length: | 1053 |
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| Molecular Weight: | 122999.00 |
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| Species: | Plasmodium falciparum (isolate 3D7) [36329] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
hydron |
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1: MGIFRSEIMK HGTLVLPSDR AREYLDCLGK EVDIQFIDMN EKTMKRQYKK YIQRIDDMER
61: ILRFLEENIN KLPNVKIKKS KIDNFLEHDN IYELDQVEES LNRLHVQFVR FCNNNKDLID
121: EKNNAIEEKH VILTALNQLS PGFIRGVGGL RGSVIGGDQQ QQHHHNNNNN NNIVSPFDEG
181: IEENNISLST HIMKDGINMM FTNISGVIKT KDQESFSRTI FRAFRGNTYT YFQNIDEDAD
241: DNDLLKNVEE LESLKSAGDT NNMYKNNKQH DTFSDKLDGK DKNDKKKKKD LKSVFVVYCQ
301: GSAQSNIYDK IMKICKAYDV KTYDWPRTYE HAKKRLKELR EIINDKEKAL KAYEEYFINE
361: IFVLINVVEP NKNSLIEEWK LFCKKERHIY NNLNYFEGSD ITLRCDCWYS ANDEEKIRHI
421: LINKSSNDLV SALLLSDKIL RPNVSPPTYI KTNEFTKSYQ SMVDTYGVPR YGEINPAIST
481: IITFPFLFGI MYGDVGHGLC IFLFALFLII MNNKVKNKKN NNEMVTMLFD GRYMLLLMGF
541: FAVYAGFLYN DFFSMPLNLF SSMFMLDKQV DNMEYYKRRE ITDSATGEVQ YAYPYIFGFD
601: CKWLGAENEL TYINSFKMKF SIIIGFIHMT FGVLMKGFNA LHFKRKMDFF FEFLPQLVMM
661: LSMIGYLVFL IIYKWVTPVG YGGFQKQGII NTIINMYLMK EINSTNQFYP YQSIIQILLL
721: SLFVLCIPFM FICKPAIRTY HIMKEKQKIN DHNVHKKNRR GKKAMAKRNN NNNNNNNNQN
781: DNKNMLLTNQ NFNEAGAKEM INAFHHNAKT GGILLSTNSK KKIVTSDGNH NNNLLSMHKR
841: NTMNNKISSS PYHNEQPDDV YDQYDEYDDD DDDDNYDENE YLNKKKKKRT DDDIEAHLLS
901: STYEEKGLQS SSAAMRGGGA GEENHHEENI SEIWIEQLIE TIEFILGLIS NTASYLRLWA
961: LSLAHQQLSF VFFEQTILNS LKRNSFMSVL INLILFSQLF SILTIAVILC MDTLECFLHS
1021: LRLQWVEFQN KFYKGDGIPF KPFNIKKLLN ENE