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3.A.1.14.28
Iron-siderophore (staphylobactin, made by S. aureus) uptake system, SirABCD (A = periplasmic receptor (R); B and C = membrane proteins with 9 or 10 TMSs (M), and D (IsdC) is likely to be the periplasmic auxiliary protein with 2 TMSs, N- and C-terminal (Dale et al. 2004). This last protein is also given the TC# 9.A.39.1.2 as a member of its own family. The ATPase subunit is not known, but it could be the protein with genbank acc# WP_001080807.1.

Accession Number:Q8KQR1
Protein Name:IsdC
Length:227
Molecular Weight:24855.00
Species:Staphylococcus aureus (strain NCTC 8325) [93061]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1 / Peptidoglycan-anchor2
Substrate

Cross database links:

RefSeq: YP_499628.1   
Entrez Gene ID: 3919244   
Pfam: PF05031   
KEGG: sao:SAOUHSC_010    sao:SAOUHSC_010   

Gene Ontology

GO:0005618 C:cell wall
GO:0005576 C:extracellular region
GO:0046872 F:metal ion binding

References (12)

[1] “Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein.”  Taylor J.M.et.al.   11952908
[2] “An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis.”  Mazmanian S.K.et.al.   11830639
[3] “In vivo heme scavenging by Staphylococcus aureus IsdC and IsdE proteins.”  Mack J.et.al.   15240116
[4] “Anchor structure of staphylococcal surface proteins. V. Anchor structure of the sortase B substrate IsdC.”  Marraffini L.A.et.al.   15718231
[5] “Heme binding in the NEAT domains of IsdA and IsdC of Staphylococcus aureus.”  Pluym M.et.al.   18194816
[6] “Crystal structure of the heme-isdC complex, the central conduit of the Isd iron/heme uptake system in Staphylococcus aureus.”  Sharp K.H.et.al.   17287214
[7] “Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein.”  Taylor J.M.et.al.   11952908
[8] “An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis.”  Mazmanian S.K.et.al.   11830639
[9] “In vivo heme scavenging by Staphylococcus aureus IsdC and IsdE proteins.”  Mack J.et.al.   15240116
[10] “Anchor structure of staphylococcal surface proteins. V. Anchor structure of the sortase B substrate IsdC.”  Marraffini L.A.et.al.   15718231
[11] “Heme binding in the NEAT domains of IsdA and IsdC of Staphylococcus aureus.”  Pluym M.et.al.   18194816
[12] “Crystal structure of the heme-isdC complex, the central conduit of the Isd iron/heme uptake system in Staphylococcus aureus.”  Sharp K.H.et.al.   17287214
Structure:
2O6P     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKNILKVFNT TILALIIIIA TFSNSANAAD SGTLNYEVYK YNTNDTSIAN DYFNKPAKYI 
61:	KKNGKLYVQI TVNHSHWITG MSIEGHKENI ISKNTAKDER TSEFEVSKLN GKIDGKIDVY 
121:	IDEKVNGKPF KYDHHYNITY KFNGPTDVAG ANAPGKDDKN SASGSDKGSD GTTTGQSESN 
181:	SSNKDKVENP QTNAGTPAYI YAIPVASLAL LIAITLFVRK KSKGNVE