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3.A.7.8.1
Competence system for DNA uptake (ComB) (Hofreuter et al., 2003; Karnholz et al., 2006). DNA uptake into the periplasm occurs preferentially at the poles. Transport into the cytoplasm depends on ComEC. Thus, DNA uptake may occur in a two step process (Stingl et al., 2010).

Accession Number:Q8RMY9
Protein Name:VirB4 aka ComB4
Length:858
Molecular Weight:98570.00
Species:Helicobacter pylori (Campylobacter pylori) [210]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate DNA

Cross database links:

Pfam: PF03135    PF01580   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0003677 F:DNA binding
GO:0007049 P:cell cycle
GO:0051301 P:cell division
GO:0007059 P:chromosome segregation

References (1)

[1] “Cluster of type IV secretion genes in Helicobacter pylori's plasticity zone.”  Kersulyte D.et.al.   12813069

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLESALKYCK EKAIDLLAGF VPKTYSMAQE CNILGLYDDT FIITKQENLV GIISLQGLSY 
61:	SNLMQKDLEG YFDTRQNVLN NISKDIQLRI VAKRRKEFIN QSPNIGNIYA KAIITQFESK 
121:	EIYKTEYFLV FETITSNVKS FFEKKKLEMT TSINEELEES SKEDKQENEN SSNETHSNTS 
181:	SKKDKKNKFK KKITFSTTSK RALLIQTIER VKNALKEFKP TLLNSKEVLN FYAEYINGKY 
241:	IAFNPKLKRL SDSYIASNVH FKKDYFVIEF QNQNTFCACV GIKAYESEEI SSLPISTLLH 
301:	TQIELDLIFH IRSLGQFESL NFLKTKKKLT LSKIVKADID NYIELVQANR LSMQECALNL 
361:	VIRAKSKAKL DKSLKEILSL LNNAGLGSVT ETIGLKPSYF SFFPNNANIN PRMRHQTSQV 
421:	IASLILFEKN NTGFRANSWG DMPLSVFKNL DHSPYLFNFH NQEVKHKGVL AHNVARVVGH 
481:	TMIIGATGAG KTTLISYLMM SALKYSNIDI LALDRLNGLY SFTKYFDGIY NQGENFHINP 
541:	FSLEDSATNR AFLLHFYAQM AKVDSYDDHK DKVEDRTALL NAIDTMYRNY NDEVKQAKFS 
601:	NQELPLPFDL KEFVNAIVKT NTDILDSSFE DYLKSSLFSS RMDSLDFKTR ISTINTDSIL 
661:	HNDDDAGLLA YYVFHKMIDR ALKINRGFLC FIDEFKSYAQ NEMMNKKINE IITQARKANG 
721:	VIVLALQDIN QLSEVRNAQS FIKNMGQLIL YPQRNIDTKD LNDKFGIRLS DTEKHFLENT 
781:	AVNEYKVLLK NMNDGSSNII DVSLSSLGNY LQIFSSNSSM VEHIDNLIKH YPKTWREVFV 
841:	SNKHENFDDK KHLEKVLK