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3.A.7.8.1 Competence system for DNA uptake (ComB) (Hofreuter et al., 2003; Karnholz et al., 2006). DNA uptake into the periplasm occurs preferentially at the poles. Transport into the cytoplasm depends on ComEC. Thus, DNA uptake may occur in a two step process (Stingl et al., 2010).
Accession Number:	Q8RMY9
Protein Name:	VirB4 aka ComB4
Length:	858
Molecular Weight:	98570.00
Species:	Helicobacter pylori (Campylobacter pylori) [210]
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	deoxyribonucleic acid

Pfam:	PF03135 PF01580
Gene Ontology GO:0016021 C:integral to membrane GO:0005524 F:ATP binding GO:0003677 F:DNA binding GO:0007049 P:cell cycle GO:0051301 P:cell division GO:0007059 P:chromosome segregation
References (1) [1] “Cluster of type IV secretion genes in Helicobacter pylori's plasticity zone.” Kersulyte D.et.al. 12813069

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MLESALKYCK EKAIDLLAGF VPKTYSMAQE CNILGLYDDT FIITKQENLV GIISLQGLSY 
61:	SNLMQKDLEG YFDTRQNVLN NISKDIQLRI VAKRRKEFIN QSPNIGNIYA KAIITQFESK 
121:	EIYKTEYFLV FETITSNVKS FFEKKKLEMT TSINEELEES SKEDKQENEN SSNETHSNTS 
181:	SKKDKKNKFK KKITFSTTSK RALLIQTIER VKNALKEFKP TLLNSKEVLN FYAEYINGKY 
241:	IAFNPKLKRL SDSYIASNVH FKKDYFVIEF QNQNTFCACV GIKAYESEEI SSLPISTLLH 
301:	TQIELDLIFH IRSLGQFESL NFLKTKKKLT LSKIVKADID NYIELVQANR LSMQECALNL 
361:	VIRAKSKAKL DKSLKEILSL LNNAGLGSVT ETIGLKPSYF SFFPNNANIN PRMRHQTSQV 
421:	IASLILFEKN NTGFRANSWG DMPLSVFKNL DHSPYLFNFH NQEVKHKGVL AHNVARVVGH 
481:	TMIIGATGAG KTTLISYLMM SALKYSNIDI LALDRLNGLY SFTKYFDGIY NQGENFHINP 
541:	FSLEDSATNR AFLLHFYAQM AKVDSYDDHK DKVEDRTALL NAIDTMYRNY NDEVKQAKFS 
601:	NQELPLPFDL KEFVNAIVKT NTDILDSSFE DYLKSSLFSS RMDSLDFKTR ISTINTDSIL 
661:	HNDDDAGLLA YYVFHKMIDR ALKINRGFLC FIDEFKSYAQ NEMMNKKINE IITQARKANG 
721:	VIVLALQDIN QLSEVRNAQS FIKNMGQLIL YPQRNIDTKD LNDKFGIRLS DTEKHFLENT 
781:	AVNEYKVLLK NMNDGSSNII DVSLSSLGNY LQIFSSNSSM VEHIDNLIKH YPKTWREVFV 
841:	SNKHENFDDK KHLEKVLK

3.A.7.8.1
Competence system for DNA uptake (ComB) (Hofreuter et al., 2003; Karnholz et al., 2006). DNA uptake into the periplasm occurs preferentially at the poles. Transport into the cytoplasm depends on ComEC. Thus, DNA uptake may occur in a two step process (Stingl et al., 2010).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

3.A.7.8.1Competence system for DNA uptake (ComB) (Hofreuter et al., 2003; Karnholz et al., 2006). DNA uptake into the periplasm occurs preferentially at the poles. Transport into the cytoplasm depends on ComEC. Thus, DNA uptake may occur in a two step process (Stingl et al., 2010).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

3.A.7.8.1
Competence system for DNA uptake (ComB) (Hofreuter et al., 2003; Karnholz et al., 2006). DNA uptake into the periplasm occurs preferentially at the poles. Transport into the cytoplasm depends on ComEC. Thus, DNA uptake may occur in a two step process (Stingl et al., 2010).