3.A.1.25.8
An ECF ABC transporter with 4 subunits, EcfS/EcfT/EcfA/EcfA'. EcfS is also called RibU; EcfT is also called CbiQ, EcfA is also called Cbi01, and EcfA' is also called Cbi02. This system can take up riboflavin and possibly other vitamins (Karpowich et al. 2015). ATP binding to the EcfAA' ATPases drives a conformational change that
dissociates the S subunit from the EcfAA'T ECF module. Upon release from
the ECF module, the RibU S subunit then binds the riboflavin transport
substrate. S subunits for distinct substrates compete
for the ATP-bound state of the ECF module (Karpowich et al. 2015). RibU appears to be capable of exporting riboflavin, FMN and FAD (Light et al. 2018).
|
| Accession Number: | Q8Y456 |
|---|
| Protein Name: | Energy-coupling factor transporter transmembrane protein EcfT |
|---|
| Length: | 265 |
|---|
| Molecular Weight: | 30176.00 |
|---|
| Species: | Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [169963] |
|---|
| Number of TMSs: | 5 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
FMN, FAD, riboflavin |
|---|
1: MMDKMILGRY IPGNSWLHRI DPRAKITAVM AFIAIVFLAN NWLTYALMFV YVLYLVLTSK
61: VPFLFFIKGL QPIFWLILIT LLLQVFFTKG GTVLVDLGLL QITTLGLANG AMMFCRFVLI
121: IFMTTLLTLT TSPIELTDGL EKILAPFRLV HLPVHELALM LSISLRFIPT LMDETEKILK
181: AQKARGVEFT SGKWSDRIKA IIPLLVPLFI SAFKRAEDLA IAMEARGYRG GKGRTRFRLL
241: RWRFADTFLL ISLAVLSGLL FWLRS