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3.A.1.4.12
ABC-type uptake porter for pyruvate and monocarboxylate 2-oxo acids.  Pyruvate uptake has been measured and is inhibited by monocarboxylate 2-oxo-acids such as 2-oxobutyrate, 2-oxovalerate, 2-oxoisovalerate, 2-oxoisocaproate and 2-oxo 3-methylvalerate which are probably substrates (Pernil et al. 2010). 

Accession Number:Q8YU23
Protein Name:Permease protein of branched-chain amino acid ABC transporter
Length:308
Molecular Weight:33063.00
Species:Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) [103690]
Number of TMSs:8
Substrate 3-methyl-2-oxovalerate, 2-oxopentanoate, pyruvate, 2-oxobutanoate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEFFSTYGS LIVSMVLGAL LGLSLYLPLM AGQLSLASPG FYALGGYIAA ILSTKVFQTN 
61:	SNSFPIPLLL LEMLIAAVVS GLLGIAVGIP ALRLRGIYLA IATIAFVEVL RVLSLNLDIT 
121:	GGAVGIFGIP QPFQTPIEYL WITLPLLLIS MVLFYRLERV RVGRAFTAIR EDELAAGAMG 
181:	INPTYYKVLA FTLGAMLAGI VGVISAHFLN TWNARQGTFD ASIIYLTFVL IGGSRTFLGS 
241:	VVGGMVFTAL PEVLRGLADT GGFPTWLAQF LRDGRLIIFG LLIVTGTIFF PQGLVTPDIF 
301:	KFGKPKNR