3.A.6.1.1 Type III protein secretion complex. Assembly of the YscR,S,T,U,V complex occurs independently of other structural components and involves the formation of a YscV oligomer (Diepold et al., 2011). A C-terminal region of Yersinia pestis YscD binds the outer membrane secretin YscC (Ross and Plano, 2011). YopBD-mediated translocation of T3SS cargo, but not YopBD pore formation, leads to activation of host pathways influencing inflammation, cell death, and response to stress (Kwuan et al. 2013).
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Accession Number: | Q93KT4 |
Protein Name: | YscU |
Length: | 354 |
Molecular Weight: | 40277.00 |
Species: | Yersinia enterocolitica [630] |
Number of TMSs: | 5 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
protein polypeptide chain |
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RefSeq: |
NP_783682.1
NP_863530.1
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Entrez Gene ID: |
1239200
1449474
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Pfam: |
PF01312
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[1] “Complete DNA sequence of Yersinia enterocolitica serotype 0:8 low-calcium-response plasmid reveals a new virulence plasmid-associated replicon.” Snellings N.J. et.al. 11402007
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1: MSGEKTEQPT PKKIRDARKK GQVAKSKEVV STALIVALSA MLMGLSDYYF EHLSRLMLIP
61: AEQSYLPFSQ ALSYVVDNVL LEFFYLCFPL LTVAALMAIA SHVVQYGFLI SGEAIKPDIK
121: KINPIEGAKR IFSIKSLVEF LKSILKVVLL SILIWIIIKG NLVTLLQLPT CGIECITPLL
181: GQILRQLMVI CTVGFVVISI ADYAFEYYQY IKELKMSKDE IKREYKEMEG SPEIKSKRRQ
241: FHQEIQSGNM RENVKRSSVV VANPTHIAIG ILYKRGETPL PLVTFKYTDA QVQTVRKIAE
301: EEGVPILQRI PLARALYWDA LVDHYIPAEQ IEATAEVLRW LERQNIEKQH SEML