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2.A.6.2.11
Solvent and antibiotic efflux pump, TtgGHI (SrpABC) (Kieboom et al. 1998; Terán et al., 2007) (solvents extruded include toluene, styrene, m-xylene, ethylbenzene and propylbenzene) (Teran et al., 2007). TtgGHI is the same as SrpABC (Kieboom et al., 1998)

Accession Number:Q93PU4
Protein Name:TtgH
Length:1049
Molecular Weight:114085.00
Species:Pseudomonas putida [303]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate styrene, m-xylene, toluene, ethylbenzene, propylbenzene

Cross database links:

Pfam: PF00873   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (2)

[1] “Three efflux pumps are required to provide efficient tolerance to toluene in Pseudomonas putida DOT-T1E.”  Rojas A.et.al.   11395460
[2] “In vivo and in vitro evidence that TtgV is the specific regulator of the TtgGHI multidrug and solvent efflux pump of Pseudomonas putida.”  Rojas A.et.al.   12896994

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSRFFIDRPI FAWVLAIVAM LAGALSLAKM PISQYPNIAA PAVSIQVSYP GASAQTVQDT 
61:	VVQVIEQQLS GLDGFRYMSA ESASDGSMTI IVTFEQGTDP DIAQVQVQNK LQLATPRLPE 
121:	EVQRQGLRVV KYQMNFFLVM SLVDRSGKLD NFDLGNLIAS QLQDPISRIP GVGDFQLFGS 
181:	PYAMRIWLDP GKLNSYQLTP TDVASAIREQ NVQVSSGQLG GLPTRSGVQL NATVLGKTRM 
241:	TTPSQFDEIL VKVNPDGSQV RVKDVGRAEL GADSFAISAQ YKDSPTASLA LRLSTGGNLL 
301:	ETVDAVKKLM EQQKAYLPDG VEVIYPYDTT PVVEASIESV VHTIFEAVVL VFLVMYLFLQ 
361:	SFRATLIPTL AVPVVLLATF ALLPYFGLNI NVLTMYAMVL AIGLLVDDAI VVVENVERLM 
421:	HDEGLSPLEA TRKSMDQISG ALVGIGMVLS AVFVPMAFFG GSAGIIYQQF AITIVVCMGL 
481:	SILVALVFTP ALCVTILKAP EGNSHHERKG FFGWFNRIFD RGTRRFERGV GAMLKGRGRY 
541:	LLAFLLITGG TGYLFTQIPK AFLPNEDQGL MMIEVRTPAN ASAERTEGVL QEVRDYLAND 
601:	EGALVEHFMT VNGFNFAGRG QNSGLVLITF KDWKERHGAG QDVFSIAQRA NQHFAKIKDA 
661:	SVMAFVPPAI LEMGNAMGFN LYLQDNLGLG HEALMAARNQ FLQLASQNPK LQAVRPNGKD 
721:	DEPQFQVNID DEKARALQVS IASINETMSA AWGSMYVNDF IDRGRVKRVY VQGEDISRIS 
781:	PEDFDKWYVR NSLGQMVPFS AFATGEWVNG SPRLERYGGI SSLNILGEPA PGYSTGDSMI 
841:	AIAEIMQQLP AGIGLSYTGL SYEEIHAGDQ APLLYALTVL IVVLCLAALY ESWSVPVSVI 
901:	MVVPLGILGA VLATLWRDLT ADVYFQVGLM TTVGLSAKNA ILIVEFAKEL YEKEGYPIVK 
961:	AAIEAAKLRL RPILMTSLAF TFGVLPMAIA SGAGAGSQHS IATGVVGGMI TATVLAVFFV 
1021:	PLFYVVVVKL FEGLMKRKPN AVKEVTHEV