The flagellar motor (smf-dependent) (PomAB; MotXY) (Okabe et al., 2005). PomB interacts with the third TMS of PomA in the Na+-driven polar flagellum (Yakushi et al. 2004). Sodium-powered stators of the flagellar motor can generate torque in the presence of the sodium channel blocker, phenamil, with mutations near the peptidoglycan-binding region of PomB (Ishida et al. 2019). FliL associates with the flagellar stator in the sodium-driven Vibrio motor (Lin et al. 2018). When the ion channel is closed, PomA and PomB interact strongly. When the ion channel opens, PomA interacts less tightly with PomB. The plug and loop between TMSs 1 and 2 regulate activation of the stator, which depends on the binding of sodium ion to the D24 residue of PomB (Nishikino et al. 2019).
|Species:||Vibrio alginolyticus  |
|Location1 / Topology2 / Orientation3:
Membrane1 / Single-pass type I membrane protein2
1: MKLRTVAASL LLTLVATTAK ANVADVGAPV PIYTEAELIK LIEQNKHLQR VRADNCQLVE
61: DIVARATRIN LPAYEFLYGD MLAWGVCVEQ DVELGLYYIE NAAHQGLPAA LEQIGRYYSR
121: GTLVQQDKER AIPYLREAAS MGNLNARIHL AELLLRDYGS PLDYEDAYRW LYNSVTADKR
181: QHKRITVLRN GLEQRMPQNV IARAKRRDTF W