3.A.1.26.12
Chloroplast heavy metal ion uptake porter with at least two components, ABCI10, 271 aas (C) and ABCI12, 391 aas (M), present in the inner chloroplast envelope. Loss of ABCI10 and ABCI11 gene products in Arabidopsis leads to dwarfed, albino plants showing impaired chloroplast biogenesis and deregulated metal homeostasis. The membrane-intrinsic protein ABCI12 may be the interaction partner for ABCI10. Thus, ABCI12 may insert into the chloroplast inner envelope membrane with five or six predicted TMSs (Voith von Voithenberg et al. 2019).
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| Accession Number: | Q944H2 |
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| Protein Name: | Protein ABCI12, chloroplastic |
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| Length: | 391 |
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| Molecular Weight: | 42938.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Plastid1 |
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| Substrate |
metal cation |
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1: MNHSNLANPT VSLTVTLIPK HPIRHLTSPI PNRNFTNPKL LFPLRLNETP SSSLAAKRVF
61: IVRATVDGDG KTGNWVNRLP IPGLGAENVF RLISSATGSP IGQFISSPVT FLHSVDPRIK
121: LVWLLTLVVL PARANLVVRL GLVLCTALLS ILVLPRQVWI DQLARVSLLS GILFITLGLG
181: SDGAPPMLQS RTPPSSITSL PNLPMSLSGY SYMLLKLGPL QFTRKGLSVG STAACLTFII
241: FQSASICLAT TTPEQLALAL RWFLFPLTYI GVPVSEIILT LLLSLRFINL VFDEVRSVSL
301: GIVSRRVNWQ QLTVLETLDI FASFIRRIFK NIFRHAEQIS QAMIVRGFRG ESSSHKIYFF
361: SGSSNKFADF ASVLCLIGVI STALLSEYFL V