3.A.1.14.10
The heme porter, Shp/SiaABC (HtsABC). Shp is a cell surface heme binding protein that transfers the heme directly to HstA (Nygaard et al., 2006). The crystal structure of the heme binding domain of Shp has been solved (Aranda et al., 2007). HtsABC is required for the uptake of staphyloferrin A (Beasley et al. 2009). The Shp cell surface heme receptor feeds iron-heme to the transporter in preparation for uptake (Sun et al. 2010; Ouattara et al., 2010).
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| Accession Number: | Q99YA2 |
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| Protein Name: | Putative ABC transporter aka SiaA |
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| Length: | 294 |
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| Molecular Weight: | 33384.00 |
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| Species: | Streptococcus pyogenes serotype M1 [301447] |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ferroheme b |
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| RefSeq: |
NP_269807.1
YP_282891.1
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| Entrez Gene ID: |
3571373
902024
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| Pfam: |
PF01497
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| BioCyc: |
SPYO160490:SPY1795-MONOMER
SPYO293653:M5005_SPY1528-MONOMER
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GO:0005381
F:iron ion transmembrane transporter activity
GO:0006827
P:high-affinity iron ion transport
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[1] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.” Ferretti J.J. et.al. 11296296
[2] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.” Sumby P. et.al. 16088826
[3] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.” Ferretti J.J. et.al. 11296296
[4] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.” Sumby P. et.al. 16088826
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1: MIKRCKGIGL ALMAFFLVAC VNQHPKTAKE TEQQRIVATS VAVVDICDRL NLDLVGVCDS
61: KLYTLPKRYD AVKRVGLPMN PDIELIASLK PTWILSPNSL QEDLEPKYQK LDTEYGFLNL
121: RSVEGMYQSI DDLGNLFQRQ QEAKELRQQY QDYYRAFQAK RKGKKKPKVL ILMGLPGSYL
181: VATNQSYVGN LLDLAGGENV YQSDEKEFLS ANPEDMLAKE PDLILRTAHA IPDKVKVMFD
241: KEFAENDIWK HFTAVKEGKV YDLDNTLFGM SAKLNYPEAL DTLTQLFDHV GDHP