3.A.1.14.10
The heme porter, Shp/SiaABC (HtsABC). Shp is a cell surface heme binding protein that transfers the heme directly to HstA (Nygaard et al., 2006). The crystal structure of the heme binding domain of Shp has been solved (Aranda et al., 2007). HtsABC is required for the uptake of staphyloferrin A (Beasley et al. 2009). The Shp cell surface heme receptor feeds iron-heme to the transporter in preparation for uptake (Sun et al. 2010; Ouattara et al., 2010).
|
| Accession Number: | Q99YA3 |
|---|
| Protein Name: | Ferrichrome transport system permease protein |
|---|
| Length: | 340 |
|---|
| Molecular Weight: | 36076.00 |
|---|
| Species: | Streptococcus pyogenes serotype M1 [301447] |
|---|
| Number of TMSs: | 9 |
|---|
| Substrate |
ferroheme b |
|---|
| Entrez Gene ID: |
3571372
902023
|
|---|
| Pfam: |
PF01032
|
|---|
|
|
[1] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.” Ferretti J.J. et.al. 11296296
[2] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.” Sumby P. et.al. 16088826
|
1: MTASDLQRDQ SLLAKKRFRS GLYLVLLILS LLFLAVIALS LGGLAVSYGA IVKGLFVAYD
61: PQVALIYDLR FPRIVIALLA GAGIAVSGVL FQAVLKNPIS DPAIIGICSG ASFMVLVSSL
121: LLPQLLLYGP IVSFLGGGVS FLLIYGLAWK KGLNPIRLIL TGIAINALFM GLSTALTSFF
181: TSASPMVNAL LAGHISQKTW ADVGVLFPYT FIGLLLALLL SKTCNLLLLD DQVIRHLGID
241: ATALRLGISL VAVLLASVAT SIVGVVSFLG LIVPHMSRLL VGSKHQILIP FSALLGAFVF
301: LLADTLGRSL AYPLEISPAI IMSIVGGPYF IYLLRRSDII