Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.10.1.10
The homo- and heteromeric glutamate receptor, GLR3.3/3.4 (Desensitized in 3 patterns: (1) by Glu alone; (2) by Ala, Cys, Glu or Gly; (3) by Ala, Cys, Glu, Gly, Ser or Asn (Stephens et al., 2008). A regulatory mechanism underlies Ca2+ homeostasis by sorting and activation of AtGLRs by AtCNIHs (see for example, 8.A.61.1.9) (Wudick et al. 2018).  May be responsible in part for Cd2+ uptake (Chen et al. 2018). GLR3.3 and GLC3.6 (TC# 1.A.10.1.24) (but not GLR3.4) play different roles in nervous system-like signaling in plant defense by a mechanism that differs substantially from that in animals (Toyota et al. 2018).

Accession Number:Q9C8E7
Protein Name:GLR3.3
Length:933
Molecular Weight:104689.00
Species:Arabidopsis thaliana [3702]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ion, calcium ion

Cross database links:

RefSeq: NP_174978.1   
Entrez Gene ID: 840859   
Pfam: PF01094    PF00060    PF00497   
KEGG: ath:AT1G42540   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0030288 C:outer membrane-bounded periplasmic space
GO:0005234 F:extracellular-glutamate-gated ion channel a...
GO:0004965 F:GABA-B receptor activity
GO:0004970 F:ionotropic glutamate receptor activity
GO:0007186 P:G-protein coupled receptor protein signalin...
GO:0006811 P:ion transport

References (2)

[1] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[2] “Phylogenetic and expression analysis of the glutamate-receptor-like gene family in Arabidopsis thaliana.”  Chiu J.C.et.al.   12082126
Structure:
6R85   6R88   6R89   6R8A     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MKQLWTFFFL SFLCSGLFRR THSEKPKVVK IGSIFSFDSV IGKVAKIAID EAVKDVNSNP 
61:	DILSGTKFSV SMQNSNCSGF MGMVEALRFM EKDIVGIIGP QCSVVAHMIS HMANELRVPL 
121:	LSFAVTDPVM SPLQFPYFIR TTQSDLYQMD AIASIVDFYG WKEVIAVFVD DDFGRNGVAA 
181:	LNDKLASRRL RITYKAGLHP DTAVNKNEIM NMLIKIMLLQ PRIVVIHVYS ELGFAVFKEA 
241:	KYLGMMGNGY VWIATDWLST NLDSSSPLPA ERLETIQGVL VLRPHTPDSD FKREFFKRWR 
301:	KMSGASLALN TYGLYAYDSV MLLARGLDKF FKDGGNISFS NHSMLNTLGK SGNLNLEAMT 
361:	VFDGGEALLK DILGTRMVGL TGQLQFTPDR SRTRPAYDII NVAGTGVRQI GYWSNHSGLS 
421:	TVLPELLYTK EKPNMSTSPK LKHVIWPGET FTKPRGWVFS NNGKELKIGV PLRVSYKEFV 
481:	SQIRGTENMF KGFCIDVFTA AVNLLPYAVP VKFIPYGNGK ENPSYTHMVE MITTGNFDGV 
541:	VGDVAIVTNR TKIVDFTQPY AASGLVVVAP FKKLNSGAWA FLRPFNRLMW AVTGCCFLFV 
601:	GIVVWILEHR TNDEFRGPPK RQCVTILWFS FSTMFFAHRE NTVSTLGRLV LIIWLFVVLI 
661:	INSSYTASLT SILTVQQLSS PIKGIESLRE RDDPIGYQVG SFAESYLRNE LNISESRLVP 
721:	LGTPEAYAKA LKDGPSKGGV AAIVDERPYV ELFLSSNCAY RIVGQEFTKS GWGFAFPRDS 
781:	PLAIDLSTAI LELAENGDLQ RIHDKWLMKN ACTLENAELE SDRLHLKSFW GLFLICGVAC 
841:	LLALFLYFVQ IIRQLYKKPT DDAIARDQQQ NHDSSSMRST RLQRFLSLMD EKEESKHESK 
901:	KRKIDGSMND TSGSTRSRGF DRERSFNSVN PLD