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2.A.6.2.27
The Triclosan resistance efflux pump TriABC-OpmH (the only known RND pump requiring two MFPs) (Mima et al., 2007).  Triclosan (TCS), a persistent synthetic antimicrobial agent that is ubiquitous in aquatic environments, is notorious for its adverse health effects on organisms (Che et al. 2025). Molecular mechanisms of sublethal triclosan exposure in mosquitofish larvae (Gambusia affinis) have been studied.

Accession Number:Q9HUJ1
Protein Name:OpmH
Length:482
Molecular Weight:53406.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate triclosan

Cross database links:

RefSeq: NP_253661.1   
Entrez Gene ID: 879703   
Pfam: PF02321   
BioCyc: PAER208964:PA4974-MONOMER   
KEGG: pae:PA4974   

Gene Ontology

GO:0019867 C:outer membrane
GO:0005215 F:transporter activity
GO:0015031 P:protein transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLRRLSLAAA VAAATGVAWA AQPTPLPTKT DLISVYKEAV DNNADLAAAQ ADYLARKEVV 
61:	PQARAGLLPQ LGAGARVGDT RIAFDERPAT VKRNSQVVQA TLSQPLFRAD RWFQWQAAKE 
121:	TSDQARLEFS ATQQDLILRS AETYFTVLRA QDNLATSKAE EAAFKRQLDQ ANERFDVGLS 
181:	DKTDVLEAQA SYDTARANRL IAEQRVDDAF QALVTLTNRD YSAIEGMRHT LPVVPPAPND 
241:	AKAWVDTAVQ QNLRLLASNY AVNAAEETLR QRKAGHLPTL DAVAQYQKGD NDALGFANSA 
301:	ANPLVHYGKY VDERSIGLEL NIPIYSGGLT SSQVRESYQR LNQSEQSREG QRRQVVQDTR 
361:	NLHRAVNTDV EQVQARRQAI ISNQSSLEAT EIGYQVGTRN IVDVLNAQRQ LYAAVRDYNN 
421:	SRYDYILDTL RLKQAAGTLS PADLEALSAY LKQDYDPDKD FLPPDLAKAA AEQLQSKPRQ 
481:	QY