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2.A.6.2.39 THe MuxABC-OpmB multidrug (aztreonam, macrolides, novobiocin and tetracycline) resistance efflux pump complex (with two RND-type proteins (MuxB and MuxC)), both required for activity (Mima et al., 2009).
Accession Number:	Q9I0V8
Protein Name:	Probable outer membrane protein
Length:	498
Molecular Weight:	53869.00
Species:	Pseudomonas aeruginosa [287]
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	macrolide, aztreonam, novobiocin, tetracycline

RefSeq:	NP_251215.1
Entrez Gene ID:	878719
Pfam:	PF02321
BioCyc:	PAER208964:PA2525-MONOMER
KEGG:	pae:PA2525
Gene Ontology GO:0016020 C:membrane GO:0008289 F:lipid binding GO:0005215 F:transporter activity GO:0006810 P:transport
References (1) [1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.” Stover C.K.et.al. 10984043

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MKHTPSLLAL ALVAALGGCA IGPDYQRPDL AVPAEFKEAE GWRRAEPRDV FQRGAWWELY 
61:	GDQTLNDLQM HLERSNQTLA QSVAQFRQAE ALVRGARAAF FPSITGNVGK TRSGQGGGDS 
121:	TVLLPGGSTV SSGGSGAIST SYSTNLSVSW EVDLWGKLRR QLEANQASLH ASAADLAAVR 
181:	LSQQSQLAQN YLQLRVMDEQ IRLLNDTVTA YERSLKVAEN KYRAGIVTRA DVAQARTQLK 
241:	STQAQAIDLK YQRAQLEHAI AVLVGLPPAQ FNLPPVASVP KLPDLPAVVP SQLLERRPDI 
301:	ASAERKVISA NAQIGVAKAA YFPDLTLSAA GGYRSGSLSN WISTPNRFWS IGPQFAMTLF 
361:	DGGLIGSQVD QAEATYDQTV ATYRQTVLDG FREVEDYLVQ LSVLDEESGV QREALESARE 
421:	ALRLAENQYK AGTVDYTDVV TNQATALSNE RTVLTLLGSR LTASVQLIAA MGGGWDSADI 
481:	ERTDERLGRV EEGLPPSP

2.A.6.2.39
THe MuxABC-OpmB multidrug (aztreonam, macrolides, novobiocin and tetracycline) resistance efflux pump complex (with two RND-type proteins (MuxB and MuxC)), both required for activity (Mima et al., 2009).

Cross database links:

Gene Ontology

References (1)

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Analyze:

2.A.6.2.39THe MuxABC-OpmB multidrug (aztreonam, macrolides, novobiocin and tetracycline) resistance efflux pump complex (with two RND-type proteins (MuxB and MuxC)), both required for activity (Mima et al., 2009).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

2.A.6.2.39
THe MuxABC-OpmB multidrug (aztreonam, macrolides, novobiocin and tetracycline) resistance efflux pump complex (with two RND-type proteins (MuxB and MuxC)), both required for activity (Mima et al., 2009).