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2.A.6.2.27
The Triclosan resistance efflux pump TriABC-OpmH (the only known RND pump requiring two MFPs) (Mima et al., 2007).  Triclosan (TCS), a persistent synthetic antimicrobial agent that is ubiquitous in aquatic environments, is notorious for its adverse health effects on organisms (Che et al. 2025). Molecular mechanisms of sublethal triclosan exposure in mosquitofish larvae (Gambusia affinis) have been studied.

Accession Number:Q9I6X4
Protein Name:TriC
Length:1015
Molecular Weight:111951.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate triclosan

Cross database links:

RefSeq: NP_248848.1   
Entrez Gene ID: 882140   
Pfam: PF00873   
BioCyc: PAER208964:PA0158-MONOMER   
KEGG: pae:PA0158   

Gene Ontology

GO:0016020 C:membrane
GO:0005215 F:transporter activity
GO:0051301 P:cell division
GO:0006810 P:transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKGGFNLSDW ALRHQSLVWY LMAVSLVMGV FSYLNLGREE DPSFAIKTMV IQTRWPGATV 
61:	DDTLEQVTDR IEKKLEELDS LDYVKSYTRP GESTVFVYLK DTTKAGDIPD IWYQVRKKIS 
121:	DIQGEFPQGI QGPGFNDEFG DVFGSVYAFT ADGLDFRQLR DYVEKVRLDI RSVKDLGKVQ 
181:	MIGAQNEVIY LNFSTRKLAA LGLDQRQVVQ SLQAQNAVTP SGVVEAGPER ISVRTSGNFR 
241:	SEKDLQAVNL RVNDRFYRLS DLASISRDFV DPPTSLFRYK GEPAIGLAVA MKEGGNILEF 
301:	GEALNARMQE ITGELPVGVG VHQVSNQAQV VKKAVGGFTR ALFEAVVIVL IVSFVSLGLR 
361:	AGLVVACSIP LVLAMVFVFM EYTDITMQRV SLGALIIALG LLVDDAMITV EMMITRLELG 
421:	DSLHDSATYA YTSTAFPMLT GTLVTVAGFV PIGLNASSAG EYTFTLFAVI AVALLLSWIV 
481:	AVLFAPVIAV HILPKTLKHK SEQKKGRIAE RFDSLLHLAM RRRWTTIFLT ALLFGVSLFL 
541:	MKFVQHQFFP SSDRPELLVD LNLPQNSSIH ETRAVMDRLE ATLKDDEDID HWSAYVGEGA 
601:	IRFYLPLDQQ LQNNFYGQLV IVTKDLEARE RVAARLRDRL RKDYVGISTY VQPLEMGPPV 
661:	GRPIQYRVSG PQIDKVREYA MGLAGVLDGN PNIGDIVYDW NEPGKMLKID IAQDKARQLG 
721:	LSSEDVAQIM NSVVTGSAVT QVRDDIYLVN VIGRAEDSER GSLETLESLQ IVTPSGTSIP 
781:	LKAFAKVSYE LEQPLVWRRD RKPTITVKAS LRGEIQPTDL VARLAPEVKR FADGLPANYR 
841:	IEVGGTVEES GKAEGPIAKV VPLMLFLMAT FLMIQLQSVQ KLFLVASVAP LGLIGVVAAL 
901:	LPTGTPMGFV AILGILALIG IIIRNSVILV TQIDAFEKDG KTPWEAVLEA THHRTRPILL 
961:	TAAAASLGMI PIAREVFWGP MAYAMIGGIV AATLLTLIFL PALYVAWYRI PEPGR