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2.A.6.2.27
The Triclosan resistance efflux pump TriABC-OpmH (the only known RND pump requiring two MFPs) (Mima et al., 2007).  Triclosan (TCS), a persistent synthetic antimicrobial agent that is ubiquitous in aquatic environments, is notorious for its adverse health effects on organisms (Che et al. 2025). Molecular mechanisms of sublethal triclosan exposure in mosquitofish larvae (Gambusia affinis) have been studied.

Accession Number:Q9I6X5
Protein Name:TriB
Length:356
Molecular Weight:38282.00
Species:Pseudomonas aeruginosa [287]
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate triclosan

Cross database links:

RefSeq: NP_248847.1   
Entrez Gene ID: 882134   
Pfam: PF00529   
BioCyc: PAER208964:PA0157-MONOMER   
KEGG: pae:PA0157   

Gene Ontology

GO:0016020 C:membrane
GO:0008565 F:protein transporter activity
GO:0051301 P:cell division
GO:0009306 P:protein secretion

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKPFSLAGLF GFALLLSGCG DEPPPAPPRP VLTVTVKTLK NDDLGRFAGS IQARYESVLG 
61:	FRTNGRIASR LFDVGDFVGK GALLATLDPT DQQNQLRASQ GDLASAEAQL IDAQANARRQ 
121:	EELFARSVTA QARLDDARTR LKTSQASFDQ AKAAVQQARD QLSYTRLVTD FDGVITTWHA 
181:	EAGQVVSAGQ AVVTLARPEV REAVFDLPTE VAESLPADAR FLVSAQLDPQ ARTTGSIREL 
241:	GPQADASTRT RRVRLSLAQT PEAFRLGSTI QVQLSSAGSV RSVLPASVLL ERDGKTQVWV 
301:	VDGKQSSVAL REVQVLSRDE RQVVIGQGLA DGDRVVRAGV NSLKPGQKIK LDEDAR