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3.A.1.134.11
Lantibiotic detoxification ABC transporter, VraD (252 aas)/VraE (626 aas; 10 TMSs)/VraH ( (Draper et al. 2015).  Upregulated in response to exposure to beta-defensin 3 (Sass et al. 2008).  Exports antimicrobial peptides such as nisin, bacitracin, daptomycin and gallidermin. Expression of vraH in the absence of vraDE is sufficient to mediate low-level resistance, but VraDEH is required to  confer high-level resistance against daptomycin and gallidermin. (Popella et al. 2016).

Accession Number:Q9KWJ6
Protein Name:ABC transporter
Length:626
Molecular Weight:70007.00
Species:Staphylococcus aureus [1280]
Number of TMSs:10
Substrate daptomycin, bacitracin, alphaprodine

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTFNHIVFKN LRQNLKHYAM YLFSLFFSIV LYFSFTTLQF TKGVNNDDSM AIIKKGALVG 
61:	SIFLFIIIVI FLMYANHLFV KRRTREFALF QLIGLTRQNI LKMLALEQMI VFLITGVVGV 
121:	LCGIAGAQLL LSIVSKLMSL SINLSIHFEP MALVLTIFML IIAYVLILFQ SALFLKRRSI 
181:	LSMMKDSIKT DATTAKVTTA EVISGVLGIA MIALGYYMAT EMFGTFKALT MAMTSPFIIL 
241:	FLTVVGAYLF FRSSVSLIFK TLKKSKNGRV SITDVVFTSS IMYRMKKNAM SLTIIAIISA 
301:	VTVTVLCFAA LSKSNTDQTL TSMAPNEFNV VATQDAKQFE TKLSQQQITF SKNAYETITV 
361:	DNVKDQVITL ENGSDSGRTN SILSANNKVT GNNAIITNTK SLPNIINIHL NKDLVVKGTK 
421:	NETFRVTQED KGRVYPLNLS FNSPVVEVSP EKYQQLKTQN NVHTFYGYDI KQTSQKEKAQ 
481:	AIAKQFGDKV ITYDEMKKEV DATNGILIFV TSFLGLAFLV AAGCIIYIKQ MDETEDELSN 
541:	FRILKRIGFT HTDMLKGLLL KITFNFGLPL LIAILHAVFA AIAFMKLMGN ISFMPVIVVI 
601:	VVYTLIYITF ALIAFVHSNK LIKKTI