3.A.1.134.11
Lantibiotic detoxification ABC transporter, VraD (252 aas)/VraE (626 aas; 10 TMSs)/VraH ( (Draper et al. 2015). Upregulated in response to exposure to beta-defensin 3 (Sass et al. 2008). Exports antimicrobial peptides such as nisin, bacitracin, daptomycin and gallidermin. Expression of vraH in the absence of vraDE is sufficient to mediate
low-level resistance, but VraDEH is required to confer high-level
resistance against daptomycin and gallidermin. (Popella et al. 2016).
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| Accession Number: | Q9KWJ6 |
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| Protein Name: | ABC transporter |
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| Length: | 626 |
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| Molecular Weight: | 70007.00 |
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| Species: | Staphylococcus aureus [1280] |
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| Number of TMSs: | 10 |
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| Substrate |
daptomycin, bacitracin, alphaprodine |
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1: MTFNHIVFKN LRQNLKHYAM YLFSLFFSIV LYFSFTTLQF TKGVNNDDSM AIIKKGALVG
61: SIFLFIIIVI FLMYANHLFV KRRTREFALF QLIGLTRQNI LKMLALEQMI VFLITGVVGV
121: LCGIAGAQLL LSIVSKLMSL SINLSIHFEP MALVLTIFML IIAYVLILFQ SALFLKRRSI
181: LSMMKDSIKT DATTAKVTTA EVISGVLGIA MIALGYYMAT EMFGTFKALT MAMTSPFIIL
241: FLTVVGAYLF FRSSVSLIFK TLKKSKNGRV SITDVVFTSS IMYRMKKNAM SLTIIAIISA
301: VTVTVLCFAA LSKSNTDQTL TSMAPNEFNV VATQDAKQFE TKLSQQQITF SKNAYETITV
361: DNVKDQVITL ENGSDSGRTN SILSANNKVT GNNAIITNTK SLPNIINIHL NKDLVVKGTK
421: NETFRVTQED KGRVYPLNLS FNSPVVEVSP EKYQQLKTQN NVHTFYGYDI KQTSQKEKAQ
481: AIAKQFGDKV ITYDEMKKEV DATNGILIFV TSFLGLAFLV AAGCIIYIKQ MDETEDELSN
541: FRILKRIGFT HTDMLKGLLL KITFNFGLPL LIAILHAVFA AIAFMKLMGN ISFMPVIVVI
601: VVYTLIYITF ALIAFVHSNK LIKKTI