3.A.29.1.2
Mitochondrial AAA protease complex of two enzymes, Yta10/12 (Afg3-like or Spg-7) and Yta11 (Ymel-1). It is a mitochondrial
ATP-dependent metalloprotease complex mediating degradation of non-assembled
mitochondrial inner membrane proteins and
necessary for the assembly of the mitochondrial respiratory chain and ATPase
complexes. It functions both in post-translational
assembly and in the turnover of mistranslated or misfolded polypeptides
(Nargund et al. 2012, Pellegrino et al. 2014, Nargund et al. 2015).
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| Accession Number: | Q9N3T5 |
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| Protein Name: | AFG3-like protein spg-7 |
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| Length: | 782 |
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| Molecular Weight: | 87469.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
protein |
|---|
1: MWRLYRKTPK QLRNSVESCF KSVNSRQFSV SSFSAVAKDD KSVLKQQEVL HLLAKDQRFE
61: ERFFNQVQQT IRYFASKPND LKKFFRKEAS TDNKESSSSS DKKDSKGNKG EDNNPFNQFP
121: GGWQQIAVSV GILLALYAFM DYQSYREISW KEFYSDFLEA GLVERLEVVD KRWVRIVSSS
181: GKYAGQTCYF NIGSVDSFER SLGAAQHHLQ YDADRQIPVL YKSEFNFKRE IPNLISVAFP
241: LLFGYYIYRM LKGGGAAGGA GRAGGGGLGG MFGGFGQSTA RVINREDIKV KFADVAGCEE
301: AKIEIMEFVN FLKNPQQYKD LGAKIPKGAI LTGPPGTGKT LLAKATAGEA NVPFITVSGS
361: EFLEMFVGVG PARVRDMFSM ARKNSPCILF IDEIDAVGRK RGGKGGMGGH SEQENTLNQL
421: LVEMDGFTTD ESSVIVIAAT NRVDILDSAL LRPGRFDRQI YVPVPDIKGR ASIFRVHLGP
481: LRTSLDKTVL SRKLAAHTPG FSGADISNVC NEAALIAARD ANHEISNKHF EQAIERVVAG
541: MEKKTQVLQK EEKKTVAYHE AGHAIAGWFL QHADPLLKVS IIPRGKGLGY AQYLPKEQYL
601: YSKDQLLDRM CMTLGGRVAE EIFFGRITTG AQDDLQKVTQ MAYSQVVKFG MSEKVGPLSF
661: ETPAPGEMAF DKPYSEATAQ LIDQEVRDLV MNALRRTRDL LLEKRSDIER VALRLLEKEI
721: LNREDMIELV GKRPFVEKNT YEEMVSGTGG LDENVELPKG LENWNKESEK KKKDEEKKKN
781: DE