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3.A.1.21.1
The Fe3+-Yersiniabactin uptake transporter, YbtPQ (Brem et al., 2001; Fetherston et al., 1999). YbtPQ is a virulence factor in the highly inflammatory microenvironment characteristic of high-titer cystitis in E. coli (Koh et al. 2016). The E. coli and Y. pestis YbtP proteins are 99.7% identical. Multiple structures of the yersiniabactin importer YbtPQ from uropathogenic Escherichia coli (UPEC) have been solved in inward-open conformations of both apo and substrate-bound states by cryo-EM (Wang et al. 2020). YbtPQ does not adopt a known fold of typical ABC importers, but instead exhibits the fold of an ABC exporter. It has two unique features: unwinding of a transmembrane helix in YbtP upon substrate release and tightly associated nucleotide-binding domains without bound nucleotides (Wang et al. 2020). This ABC porter is similar to FrpBC of Vibrio anguillarum (Lages et al. 2022).

Accession Number:Q9R7V3
Protein Name:YbtP
Length:600
Molecular Weight:66255.00
Species:Yersinia pestis [632]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Yersiniabactin

Cross database links:

RefSeq: YP_002346904.1   
Entrez Gene ID: 1174752   
Pfam: PF00664    PF00005   
KEGG: ype:YPO1913   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (1)

[1] “Genome sequence of Yersinia pestis, the causative agent of plague.”  Parkhill J.et.al.   11586360

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FASTA formatted sequence
1:	MSSQSSNTES LSRFPLWQVI TPVRRKVILA MALAGLAALT SLGALLFLAW SLRDIRATPD 
61:	AIPAWPLGGV IGCVVLTFVL RLQAFNTSHY AAFHLENILR SRLARKALQL PPGVLQQMGS 
121:	GSVAKVMLDD VKSLHIFVAD STPLYARAII MPLATIVILF WLDWRLAIAT LGVLAFGSVV 
181:	LVLARQRSED MAQRYHKARE QVSAAVIEFV QAMPVVRTFD SGSTSFLRYQ RALEEWVDVL 
241:	KTWYRKAGFS ARFSFSILNP LPTLFVLIWS GYGLLHYGSF DFIAWVAVLL LGSGMAEAVM 
301:	PMMMLNNLVA QTRLSIQRIY QVLAMPELSL PQSDQQPQEA SITFEQVSFH YPQARTGAAL 
361:	QEVSFHVPAG QIVALVGPSG AGKSTVARLL LRYADPDKGH IRIGGVDLRD MQTDTLMKQL 
421:	SFVFQDNFLF ADTIANNIRL GAPDAPLEAV IAAARVAQAH DFISALPEGY NTRVGERGVF 
481:	LSGGQRQRIT IARALLQDRP ILVLDEATAF ADPENEAALI KALAAAMRGR TVIMVAHRLS 
541:	MVTQADVILL FSDGQLREMG NHTQLLAQGG LYQRLWQHYQ QAQHWVPGGT QEEVVENERQ