3.A.1.25.5
Biotin/Riboflavin ECF transport system, EcfAA'T/RibU/BioY (Karpowich and Wang 2013). RibU binds riboflavin with high affinity, and the protein-substrate complex is
exceptionally stable in solution. The crystal structure of riboflavin-bound RibU reveals an
electronegative binding pocket at the extracellular surface in which the substrate is completely
buried (Karpowich et al. 2016).
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| Accession Number: | Q9X2I1 |
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| Protein Name: | ABC-type transporter, integral membrane subunit |
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| Length: | 271 |
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| Molecular Weight: | 30641.00 |
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| Species: | Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [243274] |
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| Number of TMSs: | 6 |
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| Substrate |
biotin, riboflavin |
|---|
1: MRLPTVLIGR YIPVDSIVHR LDPRAKLLGM IFLISAVLIV PNLLFYLVPG LAIFLLMFLS
61: RTGFKIYLAG LRSLWFFLVF AVLVQFFSSS EGEKIFWMIT DRAIWSAVYI MLRLVLIILL
121: AENFSATTPP LLSARAIESI FSTFGARKIG HEIGMVMTIA MRFVPVLALE ADRILKAQIA
181: RGANFERGKF FDRIRALVVI IVPLLISALR KAEELAVAME ARLYTGEPPK TRFKDIKWKP
241: MDTLYVLLTA GVLVLVLFGR YFVDGVFQYG S