3.A.7.15.1
The nonspecific tight adherence fibril (pilus) secretion septum (Flp-1, Flp-2, TadV-RcpCAB Tad ZA-G) (Kachlany et al., 2000; Bhattacharjee et al., 2001; Haase et al., 2003; Schreiner et al., 2003; Wang and Chen, 2005; Tomich et al. 2007). The outer membrane components of the Tad (tight adherence) secreton have been identified (Clock et al. 2008). The tad locus is required for tenacious, nonspecific adherence to surfaces and
formation of extremely strong biofilms. This locus is dedicated to the
biogenesis of Flp pili, which are required for colonization and
virulence (Perez et al. 2006). The formation of biofilms enhances gastrointestinal tolerance and
intestinal adhesion of probiotics, presenting great applied potential in
increasing the efficacy of probiotics (Gao et al. 2025).
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| Accession Number: | Q9XC05 |
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| Protein Name: | TadB |
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| Length: | 295 |
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| Molecular Weight: | 34345.00 |
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| Species: | Actinobacillus actinomycetemcomitans (Haemophilus actinomycetemcomitans) [714] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
protein polypeptide chain |
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| Pfam: |
PF00482
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[1] “Nonspecific adherence by Actinobacillus actinomycetemcomitans requires genes widespread in bacteria and archaea.” Kachlany S.C. et.al. 11029439
[2] “Genes for tight adherence of Actinobacillus actinomycetemcomitans: from plaque to plague to pond scum.” Kachlany S.C. et.al. 11553455
[3] “The Widespread Colonization Island of Actinobacillus actinomycetemcomitans.” Planet P.J. et.al. 12717435
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1: MNYYLYYAVL TIGGLLFIYT LSSWFSTKRK INEYDTSVSR TTSFFKSLKS KISLWYYHFT
61: KGDKRNLIRN IVISCFILFA FFVINVAYIH IDRLVFCLIF LVGFVLFIWK LGQYRNKKTF
121: NAMFPEVIQI LNAAATSGAG LLQALERCGK DLTGQLGEEF KSIHKRIAIG EDPVSVFEDS
181: YDRYPYKEFY FFITIVRTNL SKGGQIREVI SRLGRVIADS NKMEKKKKAM TSEARMSAII
241: VACFPVGFFF FMQFAMPENF DFLINDPTGR YVLYYVFGSE LFGMGIIWWL MRKST