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3.A.1.21.1
The Fe3+-Yersiniabactin uptake transporter, YbtPQ (Brem et al., 2001; Fetherston et al., 1999). YbtPQ is a virulence factor in the highly inflammatory microenvironment characteristic of high-titer cystitis in E. coli (Koh et al. 2016). The E. coli and Y. pestis YbtP proteins are 99.7% identical. Multiple structures of the yersiniabactin importer YbtPQ from uropathogenic Escherichia coli (UPEC) have been solved in inward-open conformations of both apo and substrate-bound states by cryo-EM (Wang et al. 2020). YbtPQ does not adopt a known fold of typical ABC importers, but instead exhibits the fold of an ABC exporter. It has two unique features: unwinding of a transmembrane helix in YbtP upon substrate release and tightly associated nucleotide-binding domains without bound nucleotides (Wang et al. 2020). This ABC porter is similar to FrpBC of Vibrio anguillarum (Lages et al. 2022).

Accession Number:Q9Z375
Protein Name:YbtQ
Length:600
Molecular Weight:66464.00
Species:Yersinia pestis [632]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Yersiniabactin

Cross database links:

RefSeq: NP_669703.1    NP_993010.1    YP_002346905.1   
Entrez Gene ID: 1147343    1174753    2764845   
Pfam: PF00664    PF00005   
BioCyc: YPES187410:Y2396-MONOMER    YPES229193:YP1657-MONOMER   
KEGG: ype:YPO1914    ypk:y2396    ypm:YP_1657   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (5)

[1] “YbtP and YbtQ: two ABC transporters required for iron uptake in Yersinia pestis.”  Fetherston J.D.et.al.   10231486
[2] “Genome sequence of Yersinia pestis, the causative agent of plague.”  Parkhill J.et.al.   11586360
[3] “Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans.”  Song Y.et.al.   15368893
[4] “Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis.”  Gehring A.M.et.al.   9818149
[5] “Genome sequence of Yersinia pestis KIM.”  Deng W.et.al.   12142430

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKDNNPADNL AWRVIWRQLI SSVGSQARML RRSMLALLLA AFMQGIAFAC LYPIIDALLR 
61:	GDAPQLLNWA MAFSVAAIVT LVLRWYGLGF EYRGHLAQAT HELRLRLGEQ LRRVPLEKLQ 
121:	RGRAGEMNAL LLGSVDENLN YVIAIANILL LTIVTPLTAS LATLWIDWRL GLVMLLIFPL 
181:	LVPFYYWRRP AMRRQMQTLG EAHQRLSGDI VEFAQGMMVL RTCGSDADKS RALLAHFNAL 
241:	ENLQTRTHRQ GAGATMLIAS VVELGLQVVV LSGIVWVVTG TLNLAFLIAA VAMIMRFAEP 
301:	MAMFISYTSV VELIASALQR IERFMAIAPL PVAEQSEMPE RYDIRFDNVS YRYEEGDGHA 
361:	LNHVSLTFPA ASMSALVGAS GAGKTTVTKL LMRYADPQQG QISIGGVDIR RLTPEQLNSL 
421:	ISVVFQDVWL FDDTLLANIR IARPQATRQE VEEAARAAQC LEFISRLPQG WLTPMGEMGG 
481:	QLSGGERQRI SIARALLKNA PVVILDEPTA ALDIESELAV QKAIDNLVHN RTVIIIAHRL 
541:	STIAGAGNIL VMEEGQVVEQ GTHAQLLSHH GRYQALWQAQ MAARVWRDDG VSASGEWVHE